"Adverse Events Category","AE/Supra-ordinate Term","Select AE","Grade","Description" "ALLERGY/IMMUNOLOGY","Allergic reaction/hypersensitivity (including drug fever)",,1,"Transient flushing or rash; drug fever <38 degrees C (<100.4 degrees F)" "ALLERGY/IMMUNOLOGY","Allergic reaction/hypersensitivity (including drug fever)",,2,"Rash; flushing; urticaria; dyspnea; drug fever >=38 degrees C (>=100.4 degrees F)" "ALLERGY/IMMUNOLOGY","Allergic reaction/hypersensitivity (including drug fever)",,3,"Symptomatic bronchospasm, with or without urticaria; parenteral medication(s) indicated; allergy-related edema/angioedema; hypotension" "ALLERGY/IMMUNOLOGY","Allergic reaction/hypersensitivity (including drug fever)",,4,"Anaphylaxis" "ALLERGY/IMMUNOLOGY","Allergic reaction/hypersensitivity (including drug fever)",,5,"Death" "ALLERGY/IMMUNOLOGY","Allergic rhinitis (including sneezing, nasal stuffiness, postnasal drip)",,1,"Mild, intervention not indicated" "ALLERGY/IMMUNOLOGY","Allergic rhinitis (including sneezing, nasal stuffiness, postnasal drip)",,2,"Moderate, intervention indicated" "ALLERGY/IMMUNOLOGY","Allergy/Immunology - Other (Specify, __)",,1,"Mild" "ALLERGY/IMMUNOLOGY","Allergy/Immunology - Other (Specify, __)",,2,"Moderate" "ALLERGY/IMMUNOLOGY","Allergy/Immunology - Other (Specify, __)",,3,"Severe" "ALLERGY/IMMUNOLOGY","Allergy/Immunology - Other (Specify, __)",,4,"Life-threatening; disabling" "ALLERGY/IMMUNOLOGY","Allergy/Immunology - Other (Specify, __)",,5,"Death" "ALLERGY/IMMUNOLOGY","Autoimmune reaction",,1,"Asymptomatic and serologic or other evidence of autoimmune reaction, with normal organ function and intervention not indicated" "ALLERGY/IMMUNOLOGY","Autoimmune reaction",,2,"Evidence of autoimmune reaction involving a non-essential organ or function (e.g., hypothyroidism)" "ALLERGY/IMMUNOLOGY","Autoimmune reaction",,3,"Reversible autoimmune reaction involving function of a major organ or other adverse event (e.g., transient colitis or anemia)" "ALLERGY/IMMUNOLOGY","Autoimmune reaction",,4,"Autoimmune reaction with life-threatening consequences" "ALLERGY/IMMUNOLOGY","Autoimmune reaction",,5,"Death" "ALLERGY/IMMUNOLOGY","Serum sickness",,3,"Present" "ALLERGY/IMMUNOLOGY","Serum sickness",,5,"Death" "ALLERGY/IMMUNOLOGY","Vasculitis",,1,"Mild, intervention not indicated" "ALLERGY/IMMUNOLOGY","Vasculitis",,2,"Symptomatic, non-steroidal medical intervention indicated" "ALLERGY/IMMUNOLOGY","Vasculitis",,3,"Steroids indicated" "ALLERGY/IMMUNOLOGY","Vasculitis",,4,"Ischemic changes; amputation indicated" "ALLERGY/IMMUNOLOGY","Vasculitis",,5,"Death" "AUDITORY/EAR","Auditory/Ear - Other (Specify, __)",,1,"Mild" "AUDITORY/EAR","Auditory/Ear - Other (Specify, __)",,2,"Moderate" "AUDITORY/EAR","Auditory/Ear - Other (Specify, __)",,3,"Severe" "AUDITORY/EAR","Auditory/Ear - Other (Specify, __)",,4,"Life-threatening; disabling" "AUDITORY/EAR","Auditory/Ear - Other (Specify, __)",,5,"Death" "AUDITORY/EAR","Hearing: patients with/without baseline audiogram and enrolled in a monitoring program",,1,"Threshold shift or loss of 15 - 25 dB relative to baseline, averaged at 2 or more contiguous test frequencies in at least one ear; or subjective change in the absence of a Grade 1 threshold shift" "AUDITORY/EAR","Hearing: patients with/without baseline audiogram and enrolled in a monitoring program",,2,"Threshold shift or loss of >25 - 90 dB, averaged at 2 contiguous test frequencies in at least one ear" "AUDITORY/EAR","Hearing: patients with/without baseline audiogram and enrolled in a monitoring program",,3,"Adult only: Threshold shift of >25 - 90 dB, averaged at 3 contiguous test frequencies in at least one ear Pediatric: Hearing loss sufficient to indicate therapeutic intervention, including hearing aids (e.g., >=20 dB bilateral HL in the speech frequencies; >=30 dB unilateral HL; and requiring additional speech-language related services)" "AUDITORY/EAR","Hearing: patients with/without baseline audiogram and enrolled in a monitoring program",,4,"Adult only: Profound bilateral hearing loss (>90 dB) Pediatric: Audiologic indication for cochlear implant and requiring additional speech-language related services" "AUDITORY/EAR","Hearing: patients without baseline audiogram and not enrolled in a monitoring program",,2,"Hearing loss not requiring hearing aid or intervention (i.e., not interfering with ADL)" "AUDITORY/EAR","Hearing: patients without baseline audiogram and not enrolled in a monitoring program",,3,"Hearing loss requiring hearing aid or intervention (i.e., interfering with ADL)" "AUDITORY/EAR","Hearing: patients without baseline audiogram and not enrolled in a monitoring program",,4,"Profound bilateral hearing loss (>90 dB)" "AUDITORY/EAR","Otitis, external ear (non-infectious)",,1,"External otitis with erythema or dry desquamation" "AUDITORY/EAR","Otitis, external ear (non-infectious)",,2,"External otitis with moist desquamation, edema, enhanced cerumen or discharge; tympanic membrane perforation; tympanostomy" "AUDITORY/EAR","Otitis, external ear (non-infectious)",,3,"External otitis with mastoiditis; stenosis or osteomyelitis" "AUDITORY/EAR","Otitis, external ear (non-infectious)",,4,"Necrosis of soft tissue or bone" "AUDITORY/EAR","Otitis, external ear (non-infectious)",,5,"Death" "AUDITORY/EAR","Otitis, middle ear (non-infectious)",,1,"Serous otitis" "AUDITORY/EAR","Otitis, middle ear (non-infectious)",,2,"Serous otitis, medical intervention indicated" "AUDITORY/EAR","Otitis, middle ear (non-infectious)",,3,"Otitis with discharge; mastoiditis" "AUDITORY/EAR","Otitis, middle ear (non-infectious)",,4,"Necrosis of the canal soft tissue or bone" "AUDITORY/EAR","Otitis, middle ear (non-infectious)",,5,"Death" "AUDITORY/EAR","Tinnitus",,2,"Tinnitus not interfering with ADL" "AUDITORY/EAR","Tinnitus",,3,"Tinnitus interfering with ADL" "AUDITORY/EAR","Tinnitus",,4,"Disabling" "BLOOD/BONE MARROW","Blood/Bone Marrow - Other (Specify, __)",,1,"Mild" "BLOOD/BONE MARROW","Blood/Bone Marrow - Other (Specify, __)",,2,"Moderate" "BLOOD/BONE MARROW","Blood/Bone Marrow - Other (Specify, __)",,3,"Severe" "BLOOD/BONE MARROW","Blood/Bone Marrow - Other (Specify, __)",,4,"Life-threatening; disabling" "BLOOD/BONE MARROW","Blood/Bone Marrow - Other (Specify, __)",,5,"Death" "BLOOD/BONE MARROW","Bone marrow cellularity",,1,"Mildly hypocellular or <=25% reduction from normal cellularity for age" "BLOOD/BONE MARROW","Bone marrow cellularity",,2,"Moderately hypocellular or >25 - <=50% reduction from normal cellularity for age" "BLOOD/BONE MARROW","Bone marrow cellularity",,3,"Severely hypocellular or >50 - <=75% reduction cellularity from normal for age" "BLOOD/BONE MARROW","Bone marrow cellularity",,5,"Death" "BLOOD/BONE MARROW","CD4 count",,1,"=2 gm decrease in hemoglobin, no transfusion" "BLOOD/BONE MARROW","Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis)",,3,"Transfusion or medical intervention (e.g., steroids) indicated" "BLOOD/BONE MARROW","Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis)",,4,"Catastrophic consequences of hemolysis (e.g., renal failure, hypotension, bronchospasm, emergency splenectomy)" "BLOOD/BONE MARROW","Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis)",,5,"Death" "BLOOD/BONE MARROW","Iron overload",,2,"Asymptomatic iron overload, intervention not indicated" "BLOOD/BONE MARROW","Iron overload",,3,"Iron overload, intervention indicated" "BLOOD/BONE MARROW","Iron overload",,4,"Organ impairment (e.g., endocrinopathy, cardiopathy)" "BLOOD/BONE MARROW","Iron overload",,5,"Death" "BLOOD/BONE MARROW","Leukocytes (total WBC)",,1,"5%)" "BLOOD/BONE MARROW","Myelodysplasia",,5,"Death" "BLOOD/BONE MARROW","Neutrophils/granulocytes (ANC/AGC)",,1,"0.45 - 0.47 second" "CARDIAC ARRHYTHMIA","Prolonged QTc interval",,2,"QTc >0.47 - 0.50 second; >=0.06 second above baseline" "CARDIAC ARRHYTHMIA","Prolonged QTc interval",,3,"QTc >0.50 second" "CARDIAC ARRHYTHMIA","Prolonged QTc interval",,4,"QTc >0.50 second; life-threatening signs or symptoms (e.g., arrhythmia, CHF, hypotension, shock syncope); Torsade de pointes" "CARDIAC ARRHYTHMIA","Prolonged QTc interval",,5,"Death" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Atrial fibrillation",1,"Asymptomatic, intervention not indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Atrial fibrillation",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Atrial fibrillation",3,"Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Atrial fibrillation",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Atrial fibrillation",5,"Death" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Atrial flutter",1,"Asymptomatic, intervention not indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Atrial flutter",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Atrial flutter",3,"Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Atrial flutter",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Atrial flutter",5,"Death" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Atrial tachycardia/Paroxysmal Atrial Tachycardia",1,"Asymptomatic, intervention not indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Atrial tachycardia/Paroxysmal Atrial Tachycardia",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Atrial tachycardia/Paroxysmal Atrial Tachycardia",3,"Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Atrial tachycardia/Paroxysmal Atrial Tachycardia",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Atrial tachycardia/Paroxysmal Atrial Tachycardia",5,"Death" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Nodal/Junctional",1,"Asymptomatic, intervention not indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Nodal/Junctional",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Nodal/Junctional",3,"Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Nodal/Junctional",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Nodal/Junctional",5,"Death" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Sinus arrhythmia",1,"Asymptomatic, intervention not indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Sinus arrhythmia",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Sinus arrhythmia",3,"Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Sinus arrhythmia",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Sinus arrhythmia",5,"Death" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Sinus bradycardia",1,"Asymptomatic, intervention not indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Sinus bradycardia",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Sinus bradycardia",3,"Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Sinus bradycardia",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Sinus bradycardia",5,"Death" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Sinus tachycardia",1,"Asymptomatic, intervention not indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Sinus tachycardia",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Sinus tachycardia",3,"Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Sinus tachycardia",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Sinus tachycardia",5,"Death" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Supraventricular arrhythmia NOS",1,"Asymptomatic, intervention not indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Supraventricular arrhythmia NOS",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Supraventricular arrhythmia NOS",3,"Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Supraventricular arrhythmia NOS",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Supraventricular arrhythmia NOS",5,"Death" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Supraventricular extrasystoles (Premature Atrial Contractions; Premature Nodal/Junctional Contractions)",1,"Asymptomatic, intervention not indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Supraventricular extrasystoles (Premature Atrial Contractions; Premature Nodal/Junctional Contractions)",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Supraventricular extrasystoles (Premature Atrial Contractions; Premature Nodal/Junctional Contractions)",3,"Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Supraventricular extrasystoles (Premature Atrial Contractions; Premature Nodal/Junctional Contractions)",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Supraventricular extrasystoles (Premature Atrial Contractions; Premature Nodal/Junctional Contractions)",5,"Death" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Supraventricular tachycardia",1,"Asymptomatic, intervention not indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Supraventricular tachycardia",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Supraventricular tachycardia",3,"Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Supraventricular tachycardia",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Supraventricular and nodal arrhythmia","Supraventricular tachycardia",5,"Death" "CARDIAC ARRHYTHMIA","Vasovagal episode",,2,"Present without loss of consciousness" "CARDIAC ARRHYTHMIA","Vasovagal episode",,3,"Present with loss of consciousness" "CARDIAC ARRHYTHMIA","Vasovagal episode",,4,"Life-threatening consequences" "CARDIAC ARRHYTHMIA","Vasovagal episode",,5,"Death" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Bigeminy",1,"Asymptomatic, no intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Bigeminy",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Bigeminy",3,"Symptomatic and incompletely controlled medically or controlled with device (e.g., defibrillator)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Bigeminy",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Bigeminy",5,"Death" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Idioventricular rhythm",1,"Asymptomatic, no intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Idioventricular rhythm",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Idioventricular rhythm",3,"Symptomatic and incompletely controlled medically or controlled with device (e.g., defibrillator)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Idioventricular rhythm",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Idioventricular rhythm",5,"Death" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","PVCs",1,"Asymptomatic, no intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","PVCs",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","PVCs",3,"Symptomatic and incompletely controlled medically or controlled with device (e.g., defibrillator)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","PVCs",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","PVCs",5,"Death" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Torsade de pointes",1,"Asymptomatic, no intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Torsade de pointes",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Torsade de pointes",3,"Symptomatic and incompletely controlled medically or controlled with device (e.g., defibrillator)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Torsade de pointes",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Torsade de pointes",5,"Death" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Trigeminy",1,"Asymptomatic, no intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Trigeminy",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Trigeminy",3,"Symptomatic and incompletely controlled medically or controlled with device (e.g., defibrillator)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Trigeminy",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Trigeminy",5,"Death" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular arrhythmia NOS",1,"Asymptomatic, no intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular arrhythmia NOS",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular arrhythmia NOS",3,"Symptomatic and incompletely controlled medically or controlled with device (e.g., defibrillator)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular arrhythmia NOS",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular arrhythmia NOS",5,"Death" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular fibrillation",1,"Asymptomatic, no intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular fibrillation",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular fibrillation",3,"Symptomatic and incompletely controlled medically or controlled with device (e.g., defibrillator)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular fibrillation",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular fibrillation",5,"Death" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular flutter",1,"Asymptomatic, no intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular flutter",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular flutter",3,"Symptomatic and incompletely controlled medically or controlled with device (e.g., defibrillator)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular flutter",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular flutter",5,"Death" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular tachycardia",1,"Asymptomatic, no intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular tachycardia",2,"Non-urgent medical intervention indicated" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular tachycardia",3,"Symptomatic and incompletely controlled medically or controlled with device (e.g., defibrillator)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular tachycardia",4,"Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)" "CARDIAC ARRHYTHMIA","Ventricular arrhythmia","Ventricular tachycardia",5,"Death" "CARDIAC GENERAL","Cardiac General - Other (Specify, __)",,1,"Mild" "CARDIAC GENERAL","Cardiac General - Other (Specify, __)",,2,"Moderate" "CARDIAC GENERAL","Cardiac General - Other (Specify, __)",,3,"Severe" "CARDIAC GENERAL","Cardiac General - Other (Specify, __)",,4,"Life-threatening; disabling" "CARDIAC GENERAL","Cardiac General - Other (Specify, __)",,5,"Death" "CARDIAC GENERAL","Cardiac ischemia/infarction",,1,"Asymptomatic arterial narrowing without ischemia" "CARDIAC GENERAL","Cardiac ischemia/infarction",,2,"Asymptomatic and testing suggesting ischemia; stable angina" "CARDIAC GENERAL","Cardiac ischemia/infarction",,3,"Symptomatic and testing consistent with ischemia; unstable angina; intervention indicated" "CARDIAC GENERAL","Cardiac ischemia/infarction",,4,"Acute myocardial infarction" "CARDIAC GENERAL","Cardiac ischemia/infarction",,5,"Death" "CARDIAC GENERAL","Cardiac troponin I (cTnI)",,3,"Levels consistent with unstable angina as defined by the manufacturer" "CARDIAC GENERAL","Cardiac troponin I (cTnI)",,4,"Levels consistent with myocardial infarction as defined by the manufacturer" "CARDIAC GENERAL","Cardiac troponin I (cTnI)",,5,"Death" "CARDIAC GENERAL","Cardiac troponin T (cTnT)",,1,"0.03 - <0.05 ng/mL" "CARDIAC GENERAL","Cardiac troponin T (cTnT)",,2,"0.05 - <0.1 ng/mL" "CARDIAC GENERAL","Cardiac troponin T (cTnT)",,3,"0.1 - <0.2 ng/mL" "CARDIAC GENERAL","Cardiac troponin T (cTnT)",,4,"0.2 ng/mL" "CARDIAC GENERAL","Cardiac troponin T (cTnT)",,5,"Death" "CARDIAC GENERAL","Cardiopulmonary arrest, cause unknown (non-fatal)",,4,"Life-threatening" "CARDIAC GENERAL","Hypertension",,1,"Asymptomatic, transient (<24 hrs) increase by >20 mmHg (diastolic) or to >150/100 if previously WNL; intervention not indicated Pediatric: Asymptomatic, transient (<24 hrs) BP increase >ULN; intervention not indicated" "CARDIAC GENERAL","Hypertension",,2,"Recurrent or persistent (>=24 hrs) or symptomatic increase by >20 mmHg (diastolic) or to >150/100 if previously WNL; monotherapy may be indicated Pediatric: Recurrent or persistent (>=24 hrs) BP >ULN; monotherapy may be indicated" "CARDIAC GENERAL","Hypertension",,3,"Requiring more than one drug or more intensive therapy than previously Pediatric: Same as adult" "CARDIAC GENERAL","Hypertension",,4,"Life-threatening consequences (e.g., hypertensive crisis) Pediatric: Same as adult" "CARDIAC GENERAL","Hypertension",,5,"Death" "CARDIAC GENERAL","Hypotension",,1,"Changes, intervention not indicated" "CARDIAC GENERAL","Hypotension",,2,"Brief (<24 hrs) fluid replacement or other therapy; no physiologic consequences" "CARDIAC GENERAL","Hypotension",,3,"Sustained (>=24 hrs) therapy, resolves without persisting physiologic consequences" "CARDIAC GENERAL","Hypotension",,4,"Shock (e.g., acidemia; impairment of vital organ function)" "CARDIAC GENERAL","Hypotension",,5,"Death" "CARDIAC GENERAL","Left ventricular diastolic dysfunction",,1,"Asymptomatic diagnostic finding; intervention not indicated" "CARDIAC GENERAL","Left ventricular diastolic dysfunction",,2,"Asymptomatic, intervention indicated" "CARDIAC GENERAL","Left ventricular diastolic dysfunction",,3,"Symptomatic CHF responsive to intervention" "CARDIAC GENERAL","Left ventricular diastolic dysfunction",,4,"Refractory CHF, poorly controlled; intervention such as ventricular assist device or heart transplant indicated" "CARDIAC GENERAL","Left ventricular diastolic dysfunction",,5,"Death" "CARDIAC GENERAL","Left ventricular systolic dysfunction",,1,"Asymptomatic, resting ejection fraction (EF) <60 - 50%; shortening fraction (SF) <30 - 24%" "CARDIAC GENERAL","Left ventricular systolic dysfunction",,2,"Asymptomatic, resting EF <50 - 40%; SF <24 - 15%" "CARDIAC GENERAL","Left ventricular systolic dysfunction",,3,"Symptomatic CHF responsive to intervention; EF <40 - 20% SF <15%" "CARDIAC GENERAL","Left ventricular systolic dysfunction",,4,"Refractory CHF or poorly controlled; EF <20%; intervention such as ventricular assist device, ventricular reduction surgery, or heart transplant indicated" "CARDIAC GENERAL","Left ventricular systolic dysfunction",,5,"Death" "CARDIAC GENERAL","Myocarditis",,3,"CHF responsive to intervention" "CARDIAC GENERAL","Myocarditis",,4,"Severe or refractory CHF" "CARDIAC GENERAL","Myocarditis",,5,"Death" "CARDIAC GENERAL","Pericardial effusion (non-malignant)",,1,"Asymptomatic effusion" "CARDIAC GENERAL","Pericardial effusion (non-malignant)",,3,"Effusion with physiologic consequences" "CARDIAC GENERAL","Pericardial effusion (non-malignant)",,4,"Life-threatening consequences (e.g., tamponade); emergency intervention indicated" "CARDIAC GENERAL","Pericardial effusion (non-malignant)",,5,"Death" "CARDIAC GENERAL","Pericarditis",,1,"Asymptomatic, ECG or physical exam (rub) changes consistent with pericarditis" "CARDIAC GENERAL","Pericarditis",,2,"Symptomatic pericarditis (e.g., chest pain)" "CARDIAC GENERAL","Pericarditis",,3,"Pericarditis with physiologic consequences (e.g., pericardial constriction)" "CARDIAC GENERAL","Pericarditis",,4,"Life-threatening consequences; emergency intervention indicated" "CARDIAC GENERAL","Pericarditis",,5,"Death" "CARDIAC GENERAL","Pulmonary hypertension",,1,"Asymptomatic without therapy" "CARDIAC GENERAL","Pulmonary hypertension",,2,"Asymptomatic, therapy indicated" "CARDIAC GENERAL","Pulmonary hypertension",,3,"Symptomatic hypertension, responsive to therapy" "CARDIAC GENERAL","Pulmonary hypertension",,4,"Symptomatic hypertension, poorly controlled" "CARDIAC GENERAL","Pulmonary hypertension",,5,"Death" "CARDIAC GENERAL","Restrictive cardiomyopathy",,1,"Asymptomatic, therapy not indicated" "CARDIAC GENERAL","Restrictive cardiomyopathy",,2,"Asymptomatic, therapy indicated" "CARDIAC GENERAL","Restrictive cardiomyopathy",,3,"Symptomatic CHF responsive to intervention" "CARDIAC GENERAL","Restrictive cardiomyopathy",,4,"Refractory CHF, poorly controlled; intervention such as ventricular assist device, or heart transplant indicated" "CARDIAC GENERAL","Restrictive cardiomyopathy",,5,"Death" "CARDIAC GENERAL","Right ventricular dysfunction (cor pulmonale)",,1,"Asymptomatic without therapy" "CARDIAC GENERAL","Right ventricular dysfunction (cor pulmonale)",,2,"Asymptomatic, therapy indicated" "CARDIAC GENERAL","Right ventricular dysfunction (cor pulmonale)",,3,"Symptomatic cor pulmonale, responsive to intervention" "CARDIAC GENERAL","Right ventricular dysfunction (cor pulmonale)",,4,"Symptomatic cor pulmonale poorly controlled; intervention such as ventricular assist device, or heart transplant indicated" "CARDIAC GENERAL","Right ventricular dysfunction (cor pulmonale)",,5,"Death" "CARDIAC GENERAL","Valvular heart disease",,1,"Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis; treatment other than endocarditis prophylaxis not indicated" "CARDIAC GENERAL","Valvular heart disease",,2,"Asymptomatic; moderate regurgitation or stenosis by imaging" "CARDIAC GENERAL","Valvular heart disease",,3,"Symptomatic; severe regurgitation or stenosis; symptoms controlled with medical therapy" "CARDIAC GENERAL","Valvular heart disease",,4,"Life-threatening; disabling; intervention (e.g., valve replacement, valvuloplasty) indicated" "CARDIAC GENERAL","Valvular heart disease",,5,"Death" "COAGULATION","Coagulation - Other (Specify, __)",,1,"Mild" "COAGULATION","Coagulation - Other (Specify, __)",,2,"Moderate" "COAGULATION","Coagulation - Other (Specify, __)",,3,"Severe" "COAGULATION","Coagulation - Other (Specify, __)",,4,"Life-threatening; disabling" "COAGULATION","Coagulation - Other (Specify, __)",,5,"Death" "COAGULATION","DIC (disseminated intravascular coagulation)",,2,"Laboratory findings with no bleeding" "COAGULATION","DIC (disseminated intravascular coagulation)",,3,"Laboratory findings and bleeding" "COAGULATION","DIC (disseminated intravascular coagulation)",,4,"Laboratory findings, life-threatening or disabling consequences (e.g., CNS hemorrhage, organ damage, or hemodynamically significant blood loss)" "COAGULATION","DIC (disseminated intravascular coagulation)",,5,"Death" "COAGULATION","Fibrinogen",,1,"<1.0 - 0.75 x LLN or <25% decrease from baseline" "COAGULATION","Fibrinogen",,2,"<0.75 - 0.5 x LLN or 25 - <50% decrease from baseline" "COAGULATION","Fibrinogen",,3,"<0.5 - 0.25 x LLN or 50 - <75% decrease from baseline" "COAGULATION","Fibrinogen",,4,"<0.25 x LLN or 75% decrease from baseline or absolute value <50 mg/dL" "COAGULATION","Fibrinogen",,5,"Death" "COAGULATION","INR (International Normalized Ratio of prothrombin time)",,1,">1 - 1.5 x ULN" "COAGULATION","INR (International Normalized Ratio of prothrombin time)",,2,">1.5 - 2 x ULN" "COAGULATION","INR (International Normalized Ratio of prothrombin time)",,3,">2 x ULN" "COAGULATION","PTT (Partial Thromboplastin Time)",,1,">1 - 1.5 x ULN" "COAGULATION","PTT (Partial Thromboplastin Time)",,2,">1.5 - 2 x ULN" "COAGULATION","PTT (Partial Thromboplastin Time)",,3,">2 x ULN" "COAGULATION","Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS])",,1,"Evidence of RBC destruction (schistocytosis) without clinical consequences" "COAGULATION","Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS])",,3,"Laboratory findings present with clinical consequences (e.g., renal insufficiency, petechiae)" "COAGULATION","Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS])",,4,"Laboratory findings and life-threatening or disabling consequences, (e.g., CNS hemorrhage/bleeding or thrombosis/embolism or renal failure)" "COAGULATION","Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS])",,5,"Death" "CONSTITUTIONAL SYMPTOMS","Constitutional Symptoms - Other (Specify, __)",,1,"Mild" "CONSTITUTIONAL SYMPTOMS","Constitutional Symptoms - Other (Specify, __)",,2,"Moderate" "CONSTITUTIONAL SYMPTOMS","Constitutional Symptoms - Other (Specify, __)",,3,"Severe" "CONSTITUTIONAL SYMPTOMS","Constitutional Symptoms - Other (Specify, __)",,4,"Life-threatening; disabling" "CONSTITUTIONAL SYMPTOMS","Constitutional Symptoms - Other (Specify, __)",,5,"Death" "CONSTITUTIONAL SYMPTOMS","Fatigue (asthenia, lethargy, malaise)",,1,"Mild fatigue over baseline" "CONSTITUTIONAL SYMPTOMS","Fatigue (asthenia, lethargy, malaise)",,2,"Moderate or causing difficulty performing some ADL" "CONSTITUTIONAL SYMPTOMS","Fatigue (asthenia, lethargy, malaise)",,3,"Severe fatigue interfering with ADL" "CONSTITUTIONAL SYMPTOMS","Fatigue (asthenia, lethargy, malaise)",,4,"Disabling" "CONSTITUTIONAL SYMPTOMS","Fever (in the absence of neutropenia, where neutropenia is defined as ANC <1.0 x 10e9/L)",,1,"38.0 - 39.0 degrees C (100.4 - 102.2 degrees F)" "CONSTITUTIONAL SYMPTOMS","Fever (in the absence of neutropenia, where neutropenia is defined as ANC <1.0 x 10e9/L)",,2,">39.0 - 40.0 degrees C (102.3 - 104.0 degrees F)" "CONSTITUTIONAL SYMPTOMS","Fever (in the absence of neutropenia, where neutropenia is defined as ANC <1.0 x 10e9/L)",,3,">40.0 degrees C (>104.0 degrees F) for <=24 hrs" "CONSTITUTIONAL SYMPTOMS","Fever (in the absence of neutropenia, where neutropenia is defined as ANC <1.0 x 10e9/L)",,4,">40.0 degrees C (>104.0 degrees F) for >24 hrs" "CONSTITUTIONAL SYMPTOMS","Fever (in the absence of neutropenia, where neutropenia is defined as ANC <1.0 x 10e9/L)",,5,"Death" "CONSTITUTIONAL SYMPTOMS","Hypothermia",,2,"35 - >32 degrees C 95 - >89.6 degrees F" "CONSTITUTIONAL SYMPTOMS","Hypothermia",,3,"32 - >28 degrees C 89.6 - >82.4 degrees F" "CONSTITUTIONAL SYMPTOMS","Hypothermia",,4,"<=28 degrees C 82.4 degrees F or life-threatening consequences (e.g., coma, hypotension, pulmonary edema, acidemia, ventricular fibrillation)" "CONSTITUTIONAL SYMPTOMS","Hypothermia",,5,"Death" "CONSTITUTIONAL SYMPTOMS","Insomnia",,1,"Occasional difficulty sleeping, not interfering with function" "CONSTITUTIONAL SYMPTOMS","Insomnia",,2,"Difficulty sleeping, interfering with function but not interfering with ADL" "CONSTITUTIONAL SYMPTOMS","Insomnia",,3,"Frequent difficulty sleeping, interfering with ADL" "CONSTITUTIONAL SYMPTOMS","Insomnia",,4,"Disabling" "CONSTITUTIONAL SYMPTOMS","Obesity",,2,"BMI 25 - 29.9 kg/m(2)" "CONSTITUTIONAL SYMPTOMS","Obesity",,3,"BMI 30 - 39.99 kg/m(2)" "CONSTITUTIONAL SYMPTOMS","Obesity",,4,"BMI >=40 kg/m(2)" "CONSTITUTIONAL SYMPTOMS","Odor (patient odor)",,1,"Mild odor" "CONSTITUTIONAL SYMPTOMS","Odor (patient odor)",,2,"Pronounced odor" "CONSTITUTIONAL SYMPTOMS","Rigors/chills",,1,"Mild" "CONSTITUTIONAL SYMPTOMS","Rigors/chills",,2,"Moderate, narcotics indicated" "CONSTITUTIONAL SYMPTOMS","Rigors/chills",,3,"Severe or prolonged, not responsive to narcotics" "CONSTITUTIONAL SYMPTOMS","Sweating (diaphoresis)",,1,"Mild and occasional" "CONSTITUTIONAL SYMPTOMS","Sweating (diaphoresis)",,2,"Frequent or drenching" "CONSTITUTIONAL SYMPTOMS","Weight gain",,1,"5 - <10% of baseline" "CONSTITUTIONAL SYMPTOMS","Weight gain",,2,"10 - <20% of baseline" "CONSTITUTIONAL SYMPTOMS","Weight gain",,3,">=20% of baseline" "CONSTITUTIONAL SYMPTOMS","Weight loss",,1,"5 to <10% from baseline; intervention not indicated" "CONSTITUTIONAL SYMPTOMS","Weight loss",,2,"10 - <20% from baseline; nutritional support indicated" "CONSTITUTIONAL SYMPTOMS","Weight loss",,3,">=20% from baseline; tube feeding or TPN indicated" "DEATH","Death not associated with CTCAE term","Death NOS",5,"Death" "DEATH","Death not associated with CTCAE term","Disease progression NOS",5,"Death" "DEATH","Death not associated with CTCAE term","Multi-organ failure",5,"Death" "DEATH","Death not associated with CTCAE term","Sudden death",5,"Death" "DERMATOLOGY/SKIN","Atrophy, skin",,1,"Detectable" "DERMATOLOGY/SKIN","Atrophy, skin",,2,"Marked" "DERMATOLOGY/SKIN","Atrophy, subcutaneous fat",,1,"Detectable" "DERMATOLOGY/SKIN","Atrophy, subcutaneous fat",,2,"Marked" "DERMATOLOGY/SKIN","Bruising (in absence of Grade 3 or 4 thrombocytopenia)",,1,"Localized or in a dependent area" "DERMATOLOGY/SKIN","Bruising (in absence of Grade 3 or 4 thrombocytopenia)",,2,"Generalized" "DERMATOLOGY/SKIN","Burn",,1,"Minimal symptoms; intervention not indicated" "DERMATOLOGY/SKIN","Burn",,2,"Medical intervention; minimal debridement indicated" "DERMATOLOGY/SKIN","Burn",,3,"Moderate to major debridement or reconstruction indicated" "DERMATOLOGY/SKIN","Burn",,4,"Life-threatening consequences" "DERMATOLOGY/SKIN","Burn",,5,"Death" "DERMATOLOGY/SKIN","Cheilitis",,1,"Asymptomatic" "DERMATOLOGY/SKIN","Cheilitis",,2,"Symptomatic, not interfering with ADL" "DERMATOLOGY/SKIN","Cheilitis",,3,"Symptomatic, interfering with ADL" "DERMATOLOGY/SKIN","Dermatology/Skin - Other (Specify, __)",,1,"Mild" "DERMATOLOGY/SKIN","Dermatology/Skin - Other (Specify, __)",,2,"Moderate" "DERMATOLOGY/SKIN","Dermatology/Skin - Other (Specify, __)",,3,"Severe" "DERMATOLOGY/SKIN","Dermatology/Skin - Other (Specify, __)",,4,"Life-threatening; disabling" "DERMATOLOGY/SKIN","Dermatology/Skin - Other (Specify, __)",,5,"Death" "DERMATOLOGY/SKIN","Dry skin",,1,"Asymptomatic" "DERMATOLOGY/SKIN","Dry skin",,2,"Symptomatic, not interfering with ADL" "DERMATOLOGY/SKIN","Dry skin",,3,"Interfering with ADL" "DERMATOLOGY/SKIN","Flushing",,1,"Asymptomatic" "DERMATOLOGY/SKIN","Flushing",,2,"Symptomatic" "DERMATOLOGY/SKIN","Hair loss/alopecia (scalp or body)",,1,"Thinning or patchy" "DERMATOLOGY/SKIN","Hair loss/alopecia (scalp or body)",,2,"Complete" "DERMATOLOGY/SKIN","Hyperpigmentation",,1,"Slight or localized" "DERMATOLOGY/SKIN","Hyperpigmentation",,2,"Marked or generalized" "DERMATOLOGY/SKIN","Hypopigmentation",,1,"Slight or localized" "DERMATOLOGY/SKIN","Hypopigmentation",,2,"Marked or generalized" "DERMATOLOGY/SKIN","Induration/fibrosis (skin and subcutaneous tissue)",,1,"Increased density on palpation" "DERMATOLOGY/SKIN","Induration/fibrosis (skin and subcutaneous tissue)",,2,"Moderate impairment of function not interfering with ADL; marked increase in density and firmness on palpation with or without minimal retraction" "DERMATOLOGY/SKIN","Induration/fibrosis (skin and subcutaneous tissue)",,3,"Dysfunction interfering with ADL; very marked density, retraction or fixation" "DERMATOLOGY/SKIN","Injection site reaction/extravasation changes",,1,"Pain; itching; erythema" "DERMATOLOGY/SKIN","Injection site reaction/extravasation changes",,2,"Pain or swelling, with inflammation or phlebitis" "DERMATOLOGY/SKIN","Injection site reaction/extravasation changes",,3,"Ulceration or necrosis that is severe; operative intervention indicated" "DERMATOLOGY/SKIN","Nail changes",,1,"Discoloration; ridging (koilonychias); pitting" "DERMATOLOGY/SKIN","Nail changes",,2,"Partial or complete loss of nail(s); pain in nailbed(s)" "DERMATOLOGY/SKIN","Nail changes",,3,"Interfering with ADL" "DERMATOLOGY/SKIN","Photosensitivity",,1,"Painless erythema" "DERMATOLOGY/SKIN","Photosensitivity",,2,"Painful erythema" "DERMATOLOGY/SKIN","Photosensitivity",,3,"Erythema with desquamation" "DERMATOLOGY/SKIN","Photosensitivity",,4,"Life-threatening; disabling" "DERMATOLOGY/SKIN","Photosensitivity",,5,"Death" "DERMATOLOGY/SKIN","Pruritus/itching",,1,"Mild or localized" "DERMATOLOGY/SKIN","Pruritus/itching",,2,"Intense or widespread" "DERMATOLOGY/SKIN","Pruritus/itching",,3,"Intense or widespread and interfering with ADL" "DERMATOLOGY/SKIN","Rash/desquamation",,1,"Macular or papular eruption or erythema without associated symptoms" "DERMATOLOGY/SKIN","Rash/desquamation",,2,"Macular or papular eruption or erythema with pruritus or other associated symptoms; localized desquamation or other lesions covering <50% of body surface area (BSA)" "DERMATOLOGY/SKIN","Rash/desquamation",,3,"Severe, generalized erythroderma or macular, papular or vesicular eruption; desquamation covering >=50% BSA" "DERMATOLOGY/SKIN","Rash/desquamation",,4,"Generalized exfoliative, ulcerative, or bullous dermatitis" "DERMATOLOGY/SKIN","Rash/desquamation",,5,"Death" "DERMATOLOGY/SKIN","Rash: acne/acneiform",,1,"Intervention not indicated" "DERMATOLOGY/SKIN","Rash: acne/acneiform",,2,"Intervention indicated" "DERMATOLOGY/SKIN","Rash: acne/acneiform",,3,"Associated with pain, disfigurement, ulceration, or desquamation" "DERMATOLOGY/SKIN","Rash: acne/acneiform",,5,"Death" "DERMATOLOGY/SKIN","Rash: dermatitis associated with radiation","Chemoradiation",1,"Faint erythema or dry desquamation" "DERMATOLOGY/SKIN","Rash: dermatitis associated with radiation","Chemoradiation",2,"Moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema" "DERMATOLOGY/SKIN","Rash: dermatitis associated with radiation","Chemoradiation",3,"Moist desquamation other than skin folds and creases; bleeding induced by minor trauma or abrasion" "DERMATOLOGY/SKIN","Rash: dermatitis associated with radiation","Chemoradiation",4,"Skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site" "DERMATOLOGY/SKIN","Rash: dermatitis associated with radiation","Chemoradiation",5,"Death" "DERMATOLOGY/SKIN","Rash: dermatitis associated with radiation","Radiation",1,"Faint erythema or dry desquamation" "DERMATOLOGY/SKIN","Rash: dermatitis associated with radiation","Radiation",2,"Moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema" "DERMATOLOGY/SKIN","Rash: dermatitis associated with radiation","Radiation",3,"Moist desquamation other than skin folds and creases; bleeding induced by minor trauma or abrasion" "DERMATOLOGY/SKIN","Rash: dermatitis associated with radiation","Radiation",4,"Skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site" "DERMATOLOGY/SKIN","Rash: dermatitis associated with radiation","Radiation",5,"Death" "DERMATOLOGY/SKIN","Rash: erythema multiforme (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis)",,2,"Scattered, but not generalized eruption" "DERMATOLOGY/SKIN","Rash: erythema multiforme (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis)",,3,"Severe (e.g., generalized rash or painful stomatitis); IV fluids, tube feedings, or TPN indicated" "DERMATOLOGY/SKIN","Rash: erythema multiforme (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis)",,4,"Life-threatening; disabling" "DERMATOLOGY/SKIN","Rash: erythema multiforme (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis)",,5,"Death" "DERMATOLOGY/SKIN","Rash: hand-foot skin reaction",,1,"Minimal skin changes or dermatitis (e.g., erythema) without pain" "DERMATOLOGY/SKIN","Rash: hand-foot skin reaction",,2,"Skin changes (e.g., peeling, blisters, bleeding, edema) or pain, not interfering with function" "DERMATOLOGY/SKIN","Rash: hand-foot skin reaction",,3,"Ulcerative dermatitis or skin changes with pain interfering with function" "DERMATOLOGY/SKIN","Skin breakdown/decubitus ulcer",,2,"Local wound care; medical intervention indicated" "DERMATOLOGY/SKIN","Skin breakdown/decubitus ulcer",,3,"Operative debridement or other invasive intervention indicated (e.g., hyperbaric oxygen)" "DERMATOLOGY/SKIN","Skin breakdown/decubitus ulcer",,4,"Life-threatening consequences; major invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)" "DERMATOLOGY/SKIN","Skin breakdown/decubitus ulcer",,5,"Death" "DERMATOLOGY/SKIN","Striae",,1,"Mild" "DERMATOLOGY/SKIN","Striae",,2,"Cosmetically significant" "DERMATOLOGY/SKIN","Telangiectasia",,1,"Few" "DERMATOLOGY/SKIN","Telangiectasia",,2,"Moderate number" "DERMATOLOGY/SKIN","Telangiectasia",,3,"Many and confluent" "DERMATOLOGY/SKIN","Ulceration",,2,"Superficial ulceration <2 cm size; local wound care; medical intervention indicated" "DERMATOLOGY/SKIN","Ulceration",,3,"Ulceration >=2 cm size; operative debridement, primary closure or other invasive intervention indicated (e.g., hyperbaric oxygen)" "DERMATOLOGY/SKIN","Ulceration",,4,"Life-threatening consequences; major invasive intervention indicated (e.g., complete resection, tissue reconstruction, flap, or grafting)" "DERMATOLOGY/SKIN","Ulceration",,5,"Death" "DERMATOLOGY/SKIN","Urticaria (hives, welts, wheals)",,1,"Intervention not indicated" "DERMATOLOGY/SKIN","Urticaria (hives, welts, wheals)",,2,"Intervention indicated for <24 hrs" "DERMATOLOGY/SKIN","Urticaria (hives, welts, wheals)",,3,"Intervention indicated for >=24 hrs" "DERMATOLOGY/SKIN","Wound complication, non-infectious",,1,"Incisional separation of <=25% of wound, no deeper than superficial fascia" "DERMATOLOGY/SKIN","Wound complication, non-infectious",,2,"Incisional separation >25% of wound with local care; asymptomatic hernia" "DERMATOLOGY/SKIN","Wound complication, non-infectious",,3,"Symptomatic hernia without evidence of strangulation; fascial disruption/dehiscence without evisceration; primary wound closure or revision by operative intervention indicated; hospitalization or hyperbaric oxygen indicated" "DERMATOLOGY/SKIN","Wound complication, non-infectious",,4,"Symptomatic hernia with evidence of strangulation; fascial disruption with evisceration; major reconstruction flap, grafting, resection, or amputation indicated" "DERMATOLOGY/SKIN","Wound complication, non-infectious",,5,"Death" "ENDOCRINE","Adrenal insufficiency",,1,"Asymptomatic, intervention not indicated" "ENDOCRINE","Adrenal insufficiency",,2,"Symptomatic, intervention indicated" "ENDOCRINE","Adrenal insufficiency",,3,"Hospitalization" "ENDOCRINE","Adrenal insufficiency",,4,"Life-threatening; disabling" "ENDOCRINE","Adrenal insufficiency",,5,"Death" "ENDOCRINE","Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae)",,2,"Present" "ENDOCRINE","Endocrine - Other (Specify, __)",,1,"Mild" "ENDOCRINE","Endocrine - Other (Specify, __)",,2,"Moderate" "ENDOCRINE","Endocrine - Other (Specify, __)",,3,"Severe" "ENDOCRINE","Endocrine - Other (Specify, __)",,4,"Life-threatening; disabling" "ENDOCRINE","Endocrine - Other (Specify, __)",,5,"Death" "ENDOCRINE","Feminization of male",,3,"Present" "ENDOCRINE","Hot flashes/flushes",,1,"Mild" "ENDOCRINE","Hot flashes/flushes",,2,"Moderate" "ENDOCRINE","Hot flashes/flushes",,3,"Interfering with ADL" "ENDOCRINE","Masculinization of female",,3,"Present" "ENDOCRINE","Neuroendocrine: gonadotropin secretion abnormality",,1,"Asymptomatic" "ENDOCRINE","Neuroendocrine: gonadotropin secretion abnormality",,2,"Symptomatic, not interfering with ADL; intervention indicated" "ENDOCRINE","Neuroendocrine: gonadotropin secretion abnormality",,3,"Symptoms interfering with ADL; osteopenia; fracture; infertility" "ENDOCRINE","Neuroendocrine: growth hormone secretion abnormality",,1,"Asymptomatic" "ENDOCRINE","Neuroendocrine: growth hormone secretion abnormality",,2,"Symptomatic, not interfering with ADL; intervention indicated" "ENDOCRINE","Neuroendocrine: prolactin hormone secretion abnormality",,1,"Asymptomatic" "ENDOCRINE","Neuroendocrine: prolactin hormone secretion abnormality",,2,"Symptomatic, not interfering with ADL; intervention indicated" "ENDOCRINE","Neuroendocrine: prolactin hormone secretion abnormality",,3,"Symptoms interfering with ADL; amenorrhea; galactorrhea" "ENDOCRINE","Neuroendocrine: prolactin hormone secretion abnormality",,5,"Death" "ENDOCRINE","Neuroendocrine:ACTH deficiency",,1,"Asymptomatic" "ENDOCRINE","Neuroendocrine:ACTH deficiency",,2,"Symptomatic, not interfering with ADL; intervention indicated" "ENDOCRINE","Neuroendocrine:ACTH deficiency",,3,"Symptoms interfering with ADL; hospitalization indicated" "ENDOCRINE","Neuroendocrine:ACTH deficiency",,4,"Life-threatening consequences (e.g., severe hypotension)" "ENDOCRINE","Neuroendocrine:ACTH deficiency",,5,"Death" "ENDOCRINE","Neuroendocrine:ADH secretion abnormality (e.g., SIADH or low ADH)",,1,"Asymptomatic" "ENDOCRINE","Neuroendocrine:ADH secretion abnormality (e.g., SIADH or low ADH)",,2,"Symptomatic, not interfering with ADL; intervention indicated" "ENDOCRINE","Neuroendocrine:ADH secretion abnormality (e.g., SIADH or low ADH)",,3,"Symptoms interfering with ADL" "ENDOCRINE","Neuroendocrine:ADH secretion abnormality (e.g., SIADH or low ADH)",,4,"Life-threatening consequences" "ENDOCRINE","Neuroendocrine:ADH secretion abnormality (e.g., SIADH or low ADH)",,5,"Death" "ENDOCRINE","Pancreatic endocrine: glucose intolerance",,1,"Asymptomatic, intervention not indicated" "ENDOCRINE","Pancreatic endocrine: glucose intolerance",,2,"Symptomatic; dietary modification or oral agent indicated" "ENDOCRINE","Pancreatic endocrine: glucose intolerance",,3,"Symptoms interfering with ADL; insulin indicated" "ENDOCRINE","Pancreatic endocrine: glucose intolerance",,4,"Life-threatening consequences (e.g., ketoacidosis, hyperosmolar non-ketotic coma)" "ENDOCRINE","Pancreatic endocrine: glucose intolerance",,5,"Death" "ENDOCRINE","Parathyroid function, low (hypoparathyroidism)",,1,"Asymptomatic, intervention not indicated" "ENDOCRINE","Parathyroid function, low (hypoparathyroidism)",,2,"Symptomatic; intervention indicated" "ENDOCRINE","Thyroid function, high (hyperthyroidism, thyrotoxicosis)",,1,"Asymptomatic, intervention not indicated" "ENDOCRINE","Thyroid function, high (hyperthyroidism, thyrotoxicosis)",,2,"Symptomatic, not interfering with ADL; thyroid suppression therapy indicated" "ENDOCRINE","Thyroid function, high (hyperthyroidism, thyrotoxicosis)",,3,"Symptoms interfering with ADL; hospitalization indicated" "ENDOCRINE","Thyroid function, high (hyperthyroidism, thyrotoxicosis)",,4,"Life-threatening consequences (e.g., thyroid storm)" "ENDOCRINE","Thyroid function, high (hyperthyroidism, thyrotoxicosis)",,5,"Death" "ENDOCRINE","Thyroid function, low (hypothyroidism)",,1,"Asymptomatic, intervention not indicated" "ENDOCRINE","Thyroid function, low (hypothyroidism)",,2,"Symptomatic, not interfering with ADL; thyroid replacement indicated" "ENDOCRINE","Thyroid function, low (hypothyroidism)",,3,"Symptoms interfering with ADL; hospitalization indicated" "ENDOCRINE","Thyroid function, low (hypothyroidism)",,4,"Life-threatening myxedema coma" "ENDOCRINE","Thyroid function, low (hypothyroidism)",,5,"Death" "GASTROINTESTINAL","Anorexia",,1,"Loss of appetite without alteration in eating habits" "GASTROINTESTINAL","Anorexia",,2,"Oral intake altered without significant weight loss or malnutrition; oral nutritional supplements indicated" "GASTROINTESTINAL","Anorexia",,3,"Associated with significant weight loss or malnutrition (e.g., inadequate oral caloric and/or fluid intake); IV fluids, tube feedings or TPN indicated" "GASTROINTESTINAL","Anorexia",,4,"Life-threatening consequences" "GASTROINTESTINAL","Anorexia",,5,"Death" "GASTROINTESTINAL","Ascites (non-malignant)",,1,"Asymptomatic" "GASTROINTESTINAL","Ascites (non-malignant)",,2,"Symptomatic, medical intervention indicated" "GASTROINTESTINAL","Ascites (non-malignant)",,3,"Symptomatic, invasive procedure indicated" "GASTROINTESTINAL","Ascites (non-malignant)",,4,"Life-threatening consequences" "GASTROINTESTINAL","Ascites (non-malignant)",,5,"Death" "GASTROINTESTINAL","Colitis",,1,"Asymptomatic, pathologic or radiographic findings only" "GASTROINTESTINAL","Colitis",,2,"Abdominal pain; mucus or blood in stool" "GASTROINTESTINAL","Colitis",,3,"Abdominal pain, fever, change in bowel habits with ileus; peritoneal signs" "GASTROINTESTINAL","Colitis",,4,"Life-threatening consequences (e.g., perforation, bleeding, ischemia, necrosis, toxic megacolon)" "GASTROINTESTINAL","Colitis",,5,"Death" "GASTROINTESTINAL","Constipation",,1,"Occasional or intermittent symptoms; occasional use of stool softeners, laxatives, dietary modification, or enema" "GASTROINTESTINAL","Constipation",,2,"Persistent symptoms with regular use of laxatives or enemas indicated" "GASTROINTESTINAL","Constipation",,3,"Symptoms interfering with ADL; obstipation with manual evacuation indicated" "GASTROINTESTINAL","Constipation",,4,"Life-threatening consequences (e.g., obstruction, toxic megacolon)" "GASTROINTESTINAL","Constipation",,5,"Death" "GASTROINTESTINAL","Dehydration",,1,"Increased oral fluids indicated; dry mucous membranes; diminished skin turgor" "GASTROINTESTINAL","Dehydration",,2,"IV fluids indicated <24 hrs" "GASTROINTESTINAL","Dehydration",,3,"IV fluids indicated >=24 hrs" "GASTROINTESTINAL","Dehydration",,4,"Life-threatening consequences (e.g., hemodynamic collapse)" "GASTROINTESTINAL","Dehydration",,5,"Death" "GASTROINTESTINAL","Dental: dentures or prosthesis",,1,"Minimal discomfort, no restriction in activities" "GASTROINTESTINAL","Dental: dentures or prosthesis",,2,"Discomfort preventing use in some activities (e.g., eating), but not others (e.g., speaking)" "GASTROINTESTINAL","Dental: dentures or prosthesis",,3,"Unable to use dentures or prosthesis at any time" "GASTROINTESTINAL","Dental: periodontal disease",,1,"Gingival recession or gingivitis; limited bleeding on probing; mild local bone loss" "GASTROINTESTINAL","Dental: periodontal disease",,2,"Moderate gingival recession or gingivitis; multiple sites of bleeding on probing; moderate bone loss" "GASTROINTESTINAL","Dental: periodontal disease",,3,"Spontaneous bleeding; severe bone loss with or without tooth loss; osteonecrosis of maxilla or mandible" "GASTROINTESTINAL","Dental: teeth",,1,"Surface stains; dental caries; restorable, without extractions" "GASTROINTESTINAL","Dental: teeth",,2,"Less than full mouth extractions; tooth fracture or crown amputation or repair indicated" "GASTROINTESTINAL","Dental: teeth",,3,"Full mouth extractions indicated" "GASTROINTESTINAL","Dental:teeth development",,1,"Hypoplasia of tooth or enamel not interfering with function" "GASTROINTESTINAL","Dental:teeth development",,2,"Functional impairment correctable with oral surgery" "GASTROINTESTINAL","Dental:teeth development",,3,"Maldevelopment with functional impairment not surgically correctable" "GASTROINTESTINAL","Diarrhea",,1,"Increase of <4 stools per day over baseline; mild increase in ostomy output compared to baseline" "GASTROINTESTINAL","Diarrhea",,2,"Increase of 4 - 6 stools per day over baseline; IV fluids indicated <24hrs; moderate increase in ostomy output compared to baseline; not interfering with ADL" "GASTROINTESTINAL","Diarrhea",,3,"Increase of >=7 stools per day over baseline; incontinence; IV fluids >=24 hrs; hospitalization; severe increase in ostomy output compared to baseline; interfering with ADL" "GASTROINTESTINAL","Diarrhea",,4,"Life-threatening consequences (e.g., hemodynamic collapse)" "GASTROINTESTINAL","Diarrhea",,5,"Death" "GASTROINTESTINAL","Distension/bloating, abdominal",,1,"Asymptomatic" "GASTROINTESTINAL","Distension/bloating, abdominal",,2,"Symptomatic, but not interfering with GI function" "GASTROINTESTINAL","Distension/bloating, abdominal",,3,"Symptomatic, interfering with GI function" "GASTROINTESTINAL","Dry mouth/salivary gland (xerostomia)",,1,"Symptomatic (dry or thick saliva) without significant dietary alteration; unstimulated saliva flow >0.2 ml/min" "GASTROINTESTINAL","Dry mouth/salivary gland (xerostomia)",,2,"Symptomatic and significant oral intake alteration (e.g., copious water, other lubricants, diet limited to purees and/or soft, moist foods); unstimulated saliva 0.1 to 0.2 ml/min" "GASTROINTESTINAL","Dry mouth/salivary gland (xerostomia)",,3,"Symptoms leading to inability to adequately aliment orally; IV fluids, tube feedings, or TPN indicated; unstimulated saliva <0.1 ml/min" "GASTROINTESTINAL","Dysphagia (difficulty swallowing)",,1,"Symptomatic, able to eat regular diet" "GASTROINTESTINAL","Dysphagia (difficulty swallowing)",,2,"Symptomatic and altered eating/swallowing (e.g., altered dietary habits, oral supplements); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Dysphagia (difficulty swallowing)",,3,"Symptomatic and severely altered eating/swallowing (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Dysphagia (difficulty swallowing)",,4,"Life-threatening consequences (e.g., obstruction, perforation)" "GASTROINTESTINAL","Dysphagia (difficulty swallowing)",,5,"Death" "GASTROINTESTINAL","Enteritis (inflammation of the small bowel)",,1,"Asymptomatic, pathologic or radiographic findings only" "GASTROINTESTINAL","Enteritis (inflammation of the small bowel)",,2,"Abdominal pain; mucus or blood in stool" "GASTROINTESTINAL","Enteritis (inflammation of the small bowel)",,3,"Abdominal pain, fever, change in bowel habits with ileus; peritoneal signs" "GASTROINTESTINAL","Enteritis (inflammation of the small bowel)",,4,"Life-threatening consequences (e.g., perforation, bleeding, ischemia, necrosis)" "GASTROINTESTINAL","Enteritis (inflammation of the small bowel)",,5,"Death" "GASTROINTESTINAL","Esophagitis",,1,"Asymptomatic pathologic, radiographic, or endoscopic findings only" "GASTROINTESTINAL","Esophagitis",,2,"Symptomatic; altered eating/swallowing (e.g., altered dietary habits, oral supplements); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Esophagitis",,3,"Symptomatic and severely altered eating/swallowing (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Esophagitis",,4,"Life-threatening consequences" "GASTROINTESTINAL","Esophagitis",,5,"Death" "GASTROINTESTINAL","Fistula, GI","Abdomen NOS",1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Fistula, GI","Abdomen NOS",2,"Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Fistula, GI","Abdomen NOS",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Fistula, GI","Abdomen NOS",4,"Life-threatening consequences" "GASTROINTESTINAL","Fistula, GI","Abdomen NOS",5,"Death" "GASTROINTESTINAL","Fistula, GI","Anus",1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Fistula, GI","Anus",2,"Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Fistula, GI","Anus",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Fistula, GI","Anus",4,"Life-threatening consequences" "GASTROINTESTINAL","Fistula, GI","Anus",5,"Death" "GASTROINTESTINAL","Fistula, GI","Biliary tree",1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Fistula, GI","Biliary tree",2,"Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Fistula, GI","Biliary tree",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Fistula, GI","Biliary tree",4,"Life-threatening consequences" "GASTROINTESTINAL","Fistula, GI","Biliary tree",5,"Death" "GASTROINTESTINAL","Fistula, GI","Colon/cecum/appendix",1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Fistula, GI","Colon/cecum/appendix",2,"Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Fistula, GI","Colon/cecum/appendix",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Fistula, GI","Colon/cecum/appendix",4,"Life-threatening consequences" "GASTROINTESTINAL","Fistula, GI","Colon/cecum/appendix",5,"Death" "GASTROINTESTINAL","Fistula, GI","Duodenum",1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Fistula, GI","Duodenum",2,"Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Fistula, GI","Duodenum",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Fistula, GI","Duodenum",4,"Life-threatening consequences" "GASTROINTESTINAL","Fistula, GI","Duodenum",5,"Death" "GASTROINTESTINAL","Fistula, GI","Esophagus",1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Fistula, GI","Esophagus",2,"Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Fistula, GI","Esophagus",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Fistula, GI","Esophagus",4,"Life-threatening consequences" "GASTROINTESTINAL","Fistula, GI","Esophagus",5,"Death" "GASTROINTESTINAL","Fistula, GI","Gallbladder",1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Fistula, GI","Gallbladder",2,"Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Fistula, GI","Gallbladder",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Fistula, GI","Gallbladder",4,"Life-threatening consequences" "GASTROINTESTINAL","Fistula, GI","Gallbladder",5,"Death" "GASTROINTESTINAL","Fistula, GI","Ileum",1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Fistula, GI","Ileum",2,"Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Fistula, GI","Ileum",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Fistula, GI","Ileum",4,"Life-threatening consequences" "GASTROINTESTINAL","Fistula, GI","Ileum",5,"Death" "GASTROINTESTINAL","Fistula, GI","Jejunum",1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Fistula, GI","Jejunum",2,"Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Fistula, GI","Jejunum",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Fistula, GI","Jejunum",4,"Life-threatening consequences" "GASTROINTESTINAL","Fistula, GI","Jejunum",5,"Death" "GASTROINTESTINAL","Fistula, GI","Oral cavity",1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Fistula, GI","Oral cavity",2,"Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Fistula, GI","Oral cavity",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Fistula, GI","Oral cavity",4,"Life-threatening consequences" "GASTROINTESTINAL","Fistula, GI","Oral cavity",5,"Death" "GASTROINTESTINAL","Fistula, GI","Pancreas",1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Fistula, GI","Pancreas",2,"Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Fistula, GI","Pancreas",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Fistula, GI","Pancreas",4,"Life-threatening consequences" "GASTROINTESTINAL","Fistula, GI","Pancreas",5,"Death" "GASTROINTESTINAL","Fistula, GI","Pharynx",1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Fistula, GI","Pharynx",2,"Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Fistula, GI","Pharynx",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Fistula, GI","Pharynx",4,"Life-threatening consequences" "GASTROINTESTINAL","Fistula, GI","Pharynx",5,"Death" "GASTROINTESTINAL","Fistula, GI","Rectum",1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Fistula, GI","Rectum",2,"Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Fistula, GI","Rectum",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Fistula, GI","Rectum",4,"Life-threatening consequences" "GASTROINTESTINAL","Fistula, GI","Rectum",5,"Death" "GASTROINTESTINAL","Fistula, GI","Salivary gland",1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Fistula, GI","Salivary gland",2,"Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Fistula, GI","Salivary gland",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Fistula, GI","Salivary gland",4,"Life-threatening consequences" "GASTROINTESTINAL","Fistula, GI","Salivary gland",5,"Death" "GASTROINTESTINAL","Fistula, GI","Small bowel NOS",1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Fistula, GI","Small bowel NOS",2,"Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Fistula, GI","Small bowel NOS",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Fistula, GI","Small bowel NOS",4,"Life-threatening consequences" "GASTROINTESTINAL","Fistula, GI","Small bowel NOS",5,"Death" "GASTROINTESTINAL","Fistula, GI","Stomach",1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Fistula, GI","Stomach",2,"Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Fistula, GI","Stomach",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Fistula, GI","Stomach",4,"Life-threatening consequences" "GASTROINTESTINAL","Fistula, GI","Stomach",5,"Death" "GASTROINTESTINAL","Flatulence",,1,"Mild" "GASTROINTESTINAL","Flatulence",,2,"Moderate" "GASTROINTESTINAL","Gastritis (including bile reflux gastritis)",,1,"Asymptomatic radiographic or endoscopic findings only" "GASTROINTESTINAL","Gastritis (including bile reflux gastritis)",,2,"Symptomatic; altered gastric function (e.g., inadequate oral caloric or fluid intake); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Gastritis (including bile reflux gastritis)",,3,"Symptomatic and severely altered gastric function (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >24 hrs" "GASTROINTESTINAL","Gastritis (including bile reflux gastritis)",,4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., gastrectomy)" "GASTROINTESTINAL","Gastritis (including bile reflux gastritis)",,5,"Death" "GASTROINTESTINAL","Gastrointestinal - Other (Specify, __)",,1,"Mild" "GASTROINTESTINAL","Gastrointestinal - Other (Specify, __)",,2,"Moderate" "GASTROINTESTINAL","Gastrointestinal - Other (Specify, __)",,3,"Severe" "GASTROINTESTINAL","Gastrointestinal - Other (Specify, __)",,4,"Life-threatening; disabling" "GASTROINTESTINAL","Gastrointestinal - Other (Specify, __)",,5,"Death" "GASTROINTESTINAL","Heartburn/dyspepsia",,1,"Mild" "GASTROINTESTINAL","Heartburn/dyspepsia",,2,"Moderate" "GASTROINTESTINAL","Heartburn/dyspepsia",,3,"Severe" "GASTROINTESTINAL","Hemorrhoids",,1,"Asymptomatic" "GASTROINTESTINAL","Hemorrhoids",,2,"Symptomatic; banding or medical intervention indicated" "GASTROINTESTINAL","Hemorrhoids",,3,"Interfering with ADL; interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Hemorrhoids",,4,"Life-threatening consequences" "GASTROINTESTINAL","Hemorrhoids",,5,"Death" "GASTROINTESTINAL","Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation)",,1,"Asymptomatic, radiographic findings only" "GASTROINTESTINAL","Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation)",,2,"Symptomatic; altered GI function (e.g., altered dietary habits); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation)",,3,"Symptomatic and severely altered GI function; IV fluids, tube feeding, or TPN indicated >24 hrs" "GASTROINTESTINAL","Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation)",,4,"Life-threatening consequences" "GASTROINTESTINAL","Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation)",,5,"Death" "GASTROINTESTINAL","Incontinence, anal",,1,"Occasional use of pads required" "GASTROINTESTINAL","Incontinence, anal",,2,"Daily use of pads required" "GASTROINTESTINAL","Incontinence, anal",,3,"Interfering with ADL; operative intervention indicated" "GASTROINTESTINAL","Incontinence, anal",,4,"Permanent bowel diversion indicated" "GASTROINTESTINAL","Incontinence, anal",,5,"Death" "GASTROINTESTINAL","Leak (including anastomotic), GI","Biliary tree",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Leak (including anastomotic), GI","Biliary tree",2,"Symptomatic; medical intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Biliary tree",3,"Symptomatic and interfering with GI function; invasive or endoscopic intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Biliary tree",4,"Life-threatening consequences" "GASTROINTESTINAL","Leak (including anastomotic), GI","Biliary tree",5,"Death" "GASTROINTESTINAL","Leak (including anastomotic), GI","Esophagus",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Leak (including anastomotic), GI","Esophagus",2,"Symptomatic; medical intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Esophagus",3,"Symptomatic and interfering with GI function; invasive or endoscopic intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Esophagus",4,"Life-threatening consequences" "GASTROINTESTINAL","Leak (including anastomotic), GI","Esophagus",5,"Death" "GASTROINTESTINAL","Leak (including anastomotic), GI","Large bowel",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Leak (including anastomotic), GI","Large bowel",2,"Symptomatic; medical intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Large bowel",3,"Symptomatic and interfering with GI function; invasive or endoscopic intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Large bowel",4,"Life-threatening consequences" "GASTROINTESTINAL","Leak (including anastomotic), GI","Large bowel",5,"Death" "GASTROINTESTINAL","Leak (including anastomotic), GI","Leak NOS",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Leak (including anastomotic), GI","Leak NOS",2,"Symptomatic; medical intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Leak NOS",3,"Symptomatic and interfering with GI function; invasive or endoscopic intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Leak NOS",4,"Life-threatening consequences" "GASTROINTESTINAL","Leak (including anastomotic), GI","Leak NOS",5,"Death" "GASTROINTESTINAL","Leak (including anastomotic), GI","Pancreas",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Leak (including anastomotic), GI","Pancreas",2,"Symptomatic; medical intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Pancreas",3,"Symptomatic and interfering with GI function; invasive or endoscopic intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Pancreas",4,"Life-threatening consequences" "GASTROINTESTINAL","Leak (including anastomotic), GI","Pancreas",5,"Death" "GASTROINTESTINAL","Leak (including anastomotic), GI","Pharynx",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Leak (including anastomotic), GI","Pharynx",2,"Symptomatic; medical intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Pharynx",3,"Symptomatic and interfering with GI function; invasive or endoscopic intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Pharynx",4,"Life-threatening consequences" "GASTROINTESTINAL","Leak (including anastomotic), GI","Pharynx",5,"Death" "GASTROINTESTINAL","Leak (including anastomotic), GI","Rectum",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Leak (including anastomotic), GI","Rectum",2,"Symptomatic; medical intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Rectum",3,"Symptomatic and interfering with GI function; invasive or endoscopic intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Rectum",4,"Life-threatening consequences" "GASTROINTESTINAL","Leak (including anastomotic), GI","Rectum",5,"Death" "GASTROINTESTINAL","Leak (including anastomotic), GI","Small bowel",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Leak (including anastomotic), GI","Small bowel",2,"Symptomatic; medical intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Small bowel",3,"Symptomatic and interfering with GI function; invasive or endoscopic intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Small bowel",4,"Life-threatening consequences" "GASTROINTESTINAL","Leak (including anastomotic), GI","Small bowel",5,"Death" "GASTROINTESTINAL","Leak (including anastomotic), GI","Stoma",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Leak (including anastomotic), GI","Stoma",2,"Symptomatic; medical intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Stoma",3,"Symptomatic and interfering with GI function; invasive or endoscopic intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Stoma",4,"Life-threatening consequences" "GASTROINTESTINAL","Leak (including anastomotic), GI","Stoma",5,"Death" "GASTROINTESTINAL","Leak (including anastomotic), GI","Stomach",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Leak (including anastomotic), GI","Stomach",2,"Symptomatic; medical intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Stomach",3,"Symptomatic and interfering with GI function; invasive or endoscopic intervention indicated" "GASTROINTESTINAL","Leak (including anastomotic), GI","Stomach",4,"Life-threatening consequences" "GASTROINTESTINAL","Leak (including anastomotic), GI","Stomach",5,"Death" "GASTROINTESTINAL","Malabsorption",,2,"Altered diet; oral therapies indicated (e.g., enzymes, medications, dietary supplements)" "GASTROINTESTINAL","Malabsorption",,3,"Inability to aliment adequately via GI tract (i.e., TPN indicated)" "GASTROINTESTINAL","Malabsorption",,4,"Life-threatening consequences" "GASTROINTESTINAL","Malabsorption",,5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Anus",1,"Erythema of the mucosa" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Anus",2,"Patchy ulcerations or pseudomembranes" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Anus",3,"Confluent ulcerations or pseudomembranes; bleeding with minor trauma" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Anus",4,"Tissue necrosis; significant spontaneous bleeding; life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Anus",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Esophagus",1,"Erythema of the mucosa" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Esophagus",2,"Patchy ulcerations or pseudomembranes" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Esophagus",3,"Confluent ulcerations or pseudomembranes; bleeding with minor trauma" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Esophagus",4,"Tissue necrosis; significant spontaneous bleeding; life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Esophagus",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Large bowel",1,"Erythema of the mucosa" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Large bowel",2,"Patchy ulcerations or pseudomembranes" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Large bowel",3,"Confluent ulcerations or pseudomembranes; bleeding with minor trauma" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Large bowel",4,"Tissue necrosis; significant spontaneous bleeding; life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Large bowel",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Larynx",1,"Erythema of the mucosa" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Larynx",2,"Patchy ulcerations or pseudomembranes" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Larynx",3,"Confluent ulcerations or pseudomembranes; bleeding with minor trauma" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Larynx",4,"Tissue necrosis; significant spontaneous bleeding; life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Larynx",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Oral cavity",1,"Erythema of the mucosa" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Oral cavity",2,"Patchy ulcerations or pseudomembranes" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Oral cavity",3,"Confluent ulcerations or pseudomembranes; bleeding with minor trauma" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Oral cavity",4,"Tissue necrosis; significant spontaneous bleeding; life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Oral cavity",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Pharynx",1,"Erythema of the mucosa" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Pharynx",2,"Patchy ulcerations or pseudomembranes" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Pharynx",3,"Confluent ulcerations or pseudomembranes; bleeding with minor trauma" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Pharynx",4,"Tissue necrosis; significant spontaneous bleeding; life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Pharynx",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Rectum",1,"Erythema of the mucosa" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Rectum",2,"Patchy ulcerations or pseudomembranes" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Rectum",3,"Confluent ulcerations or pseudomembranes; bleeding with minor trauma" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Rectum",4,"Tissue necrosis; significant spontaneous bleeding; life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Rectum",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Small bowel",1,"Erythema of the mucosa" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Small bowel",2,"Patchy ulcerations or pseudomembranes" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Small bowel",3,"Confluent ulcerations or pseudomembranes; bleeding with minor trauma" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Small bowel",4,"Tissue necrosis; significant spontaneous bleeding; life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Small bowel",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Stomach",1,"Erythema of the mucosa" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Stomach",2,"Patchy ulcerations or pseudomembranes" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Stomach",3,"Confluent ulcerations or pseudomembranes; bleeding with minor trauma" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Stomach",4,"Tissue necrosis; significant spontaneous bleeding; life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Stomach",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Trachea",1,"Erythema of the mucosa" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Trachea",2,"Patchy ulcerations or pseudomembranes" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Trachea",3,"Confluent ulcerations or pseudomembranes; bleeding with minor trauma" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Trachea",4,"Tissue necrosis; significant spontaneous bleeding; life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (clinical exam)","Trachea",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Anus",1,"Upper aerodigestive tract sites: Minimal symptoms, normal diet; minimal respiratory symptoms but not interfering with function Lower GI sites: Minimal discomfort, intervention not indicated" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Anus",2,"Upper aerodigestive tract sites: Symptomatic but can eat and swallow modified diet; respiratory symptoms interfering with function but not interfering with ADL Lower GI sites: Symptomatic, medical intervention indicated but not interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Anus",3,"Upper aerodigestive tract sites: Symptomatic and unable to adequately aliment or hydrate orally; respiratory symptoms interfering with ADL Lower GI sites: Stool incontinence or other symptoms interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Anus",4,"Symptoms associated with life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Anus",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Esophagus",1,"Upper aerodigestive tract sites: Minimal symptoms, normal diet; minimal respiratory symptoms but not interfering with function Lower GI sites: Minimal discomfort, intervention not indicated" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Esophagus",2,"Upper aerodigestive tract sites: Symptomatic but can eat and swallow modified diet; respiratory symptoms interfering with function but not interfering with ADL Lower GI sites: Symptomatic, medical intervention indicated but not interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Esophagus",3,"Upper aerodigestive tract sites: Symptomatic and unable to adequately aliment or hydrate orally; respiratory symptoms interfering with ADL Lower GI sites: Stool incontinence or other symptoms interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Esophagus",4,"Symptoms associated with life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Esophagus",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Large bowel",1,"Upper aerodigestive tract sites: Minimal symptoms, normal diet; minimal respiratory symptoms but not interfering with function Lower GI sites: Minimal discomfort, intervention not indicated" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Large bowel",2,"Upper aerodigestive tract sites: Symptomatic but can eat and swallow modified diet; respiratory symptoms interfering with function but not interfering with ADL Lower GI sites: Symptomatic, medical intervention indicated but not interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Large bowel",3,"Upper aerodigestive tract sites: Symptomatic and unable to adequately aliment or hydrate orally; respiratory symptoms interfering with ADL Lower GI sites: Stool incontinence or other symptoms interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Large bowel",4,"Symptoms associated with life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Large bowel",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Larynx",1,"Upper aerodigestive tract sites: Minimal symptoms, normal diet; minimal respiratory symptoms but not interfering with function Lower GI sites: Minimal discomfort, intervention not indicated" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Larynx",2,"Upper aerodigestive tract sites: Symptomatic but can eat and swallow modified diet; respiratory symptoms interfering with function but not interfering with ADL Lower GI sites: Symptomatic, medical intervention indicated but not interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Larynx",3,"Upper aerodigestive tract sites: Symptomatic and unable to adequately aliment or hydrate orally; respiratory symptoms interfering with ADL Lower GI sites: Stool incontinence or other symptoms interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Larynx",4,"Symptoms associated with life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Larynx",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Oral cavity",1,"Upper aerodigestive tract sites: Minimal symptoms, normal diet; minimal respiratory symptoms but not interfering with function Lower GI sites: Minimal discomfort, intervention not indicated" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Oral cavity",2,"Upper aerodigestive tract sites: Symptomatic but can eat and swallow modified diet; respiratory symptoms interfering with function but not interfering with ADL Lower GI sites: Symptomatic, medical intervention indicated but not interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Oral cavity",3,"Upper aerodigestive tract sites: Symptomatic and unable to adequately aliment or hydrate orally; respiratory symptoms interfering with ADL Lower GI sites: Stool incontinence or other symptoms interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Oral cavity",4,"Symptoms associated with life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Oral cavity",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Pharynx",1,"Upper aerodigestive tract sites: Minimal symptoms, normal diet; minimal respiratory symptoms but not interfering with function Lower GI sites: Minimal discomfort, intervention not indicated" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Pharynx",2,"Upper aerodigestive tract sites: Symptomatic but can eat and swallow modified diet; respiratory symptoms interfering with function but not interfering with ADL Lower GI sites: Symptomatic, medical intervention indicated but not interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Pharynx",3,"Upper aerodigestive tract sites: Symptomatic and unable to adequately aliment or hydrate orally; respiratory symptoms interfering with ADL Lower GI sites: Stool incontinence or other symptoms interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Pharynx",4,"Symptoms associated with life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Pharynx",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Rectum",1,"Upper aerodigestive tract sites: Minimal symptoms, normal diet; minimal respiratory symptoms but not interfering with function Lower GI sites: Minimal discomfort, intervention not indicated" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Rectum",2,"Upper aerodigestive tract sites: Symptomatic but can eat and swallow modified diet; respiratory symptoms interfering with function but not interfering with ADL Lower GI sites: Symptomatic, medical intervention indicated but not interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Rectum",3,"Upper aerodigestive tract sites: Symptomatic and unable to adequately aliment or hydrate orally; respiratory symptoms interfering with ADL Lower GI sites: Stool incontinence or other symptoms interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Rectum",4,"Symptoms associated with life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Rectum",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Small bowel",1,"Upper aerodigestive tract sites: Minimal symptoms, normal diet; minimal respiratory symptoms but not interfering with function Lower GI sites: Minimal discomfort, intervention not indicated" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Small bowel",2,"Upper aerodigestive tract sites: Symptomatic but can eat and swallow modified diet; respiratory symptoms interfering with function but not interfering with ADL Lower GI sites: Symptomatic, medical intervention indicated but not interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Small bowel",3,"Upper aerodigestive tract sites: Symptomatic and unable to adequately aliment or hydrate orally; respiratory symptoms interfering with ADL Lower GI sites: Stool incontinence or other symptoms interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Small bowel",4,"Symptoms associated with life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Small bowel",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Stomach",1,"Upper aerodigestive tract sites: Minimal symptoms, normal diet; minimal respiratory symptoms but not interfering with function Lower GI sites: Minimal discomfort, intervention not indicated" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Stomach",2,"Upper aerodigestive tract sites: Symptomatic but can eat and swallow modified diet; respiratory symptoms interfering with function but not interfering with ADL Lower GI sites: Symptomatic, medical intervention indicated but not interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Stomach",3,"Upper aerodigestive tract sites: Symptomatic and unable to adequately aliment or hydrate orally; respiratory symptoms interfering with ADL Lower GI sites: Stool incontinence or other symptoms interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Stomach",4,"Symptoms associated with life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Stomach",5,"Death" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Trachea",1,"Upper aerodigestive tract sites: Minimal symptoms, normal diet; minimal respiratory symptoms but not interfering with function Lower GI sites: Minimal discomfort, intervention not indicated" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Trachea",2,"Upper aerodigestive tract sites: Symptomatic but can eat and swallow modified diet; respiratory symptoms interfering with function but not interfering with ADL Lower GI sites: Symptomatic, medical intervention indicated but not interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Trachea",3,"Upper aerodigestive tract sites: Symptomatic and unable to adequately aliment or hydrate orally; respiratory symptoms interfering with ADL Lower GI sites: Stool incontinence or other symptoms interfering with ADL" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Trachea",4,"Symptoms associated with life-threatening consequences" "GASTROINTESTINAL","Mucositis/stomatitis (functional/symptomatic)","Trachea",5,"Death" "GASTROINTESTINAL","Nausea",,1,"Loss of appetite without alteration in eating habits" "GASTROINTESTINAL","Nausea",,2,"Oral intake decreased without significant weight loss, dehydration or malnutrition; IV fluids indicated <24 hrs" "GASTROINTESTINAL","Nausea",,3,"Inadequate oral caloric or fluid intake; IV fluids, tube feedings, or TPN indicated >=24 hrs" "GASTROINTESTINAL","Nausea",,4,"Life-threatening consequences" "GASTROINTESTINAL","Nausea",,5,"Death" "GASTROINTESTINAL","Necrosis, GI","Anus",3,"Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Necrosis, GI","Anus",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Necrosis, GI","Anus",5,"Death" "GASTROINTESTINAL","Necrosis, GI","Colon/cecum/appendix",3,"Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Necrosis, GI","Colon/cecum/appendix",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Necrosis, GI","Colon/cecum/appendix",5,"Death" "GASTROINTESTINAL","Necrosis, GI","Duodenum",3,"Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Necrosis, GI","Duodenum",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Necrosis, GI","Duodenum",5,"Death" "GASTROINTESTINAL","Necrosis, GI","Esophagus",3,"Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Necrosis, GI","Esophagus",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Necrosis, GI","Esophagus",5,"Death" "GASTROINTESTINAL","Necrosis, GI","Gallbladder",3,"Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Necrosis, GI","Gallbladder",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Necrosis, GI","Gallbladder",5,"Death" "GASTROINTESTINAL","Necrosis, GI","Hepatic",3,"Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Necrosis, GI","Hepatic",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Necrosis, GI","Hepatic",5,"Death" "GASTROINTESTINAL","Necrosis, GI","Ileum",3,"Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Necrosis, GI","Ileum",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Necrosis, GI","Ileum",5,"Death" "GASTROINTESTINAL","Necrosis, GI","Jejunum",3,"Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Necrosis, GI","Jejunum",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Necrosis, GI","Jejunum",5,"Death" "GASTROINTESTINAL","Necrosis, GI","Oral",3,"Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Necrosis, GI","Oral",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Necrosis, GI","Oral",5,"Death" "GASTROINTESTINAL","Necrosis, GI","Pancreas",3,"Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Necrosis, GI","Pancreas",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Necrosis, GI","Pancreas",5,"Death" "GASTROINTESTINAL","Necrosis, GI","Peritoneal cavity",3,"Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Necrosis, GI","Peritoneal cavity",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Necrosis, GI","Peritoneal cavity",5,"Death" "GASTROINTESTINAL","Necrosis, GI","Pharynx",3,"Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Necrosis, GI","Pharynx",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Necrosis, GI","Pharynx",5,"Death" "GASTROINTESTINAL","Necrosis, GI","Rectum",3,"Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Necrosis, GI","Rectum",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Necrosis, GI","Rectum",5,"Death" "GASTROINTESTINAL","Necrosis, GI","Small bowel NOS",3,"Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Necrosis, GI","Small bowel NOS",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Necrosis, GI","Small bowel NOS",5,"Death" "GASTROINTESTINAL","Necrosis, GI","Stoma",3,"Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Necrosis, GI","Stoma",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Necrosis, GI","Stoma",5,"Death" "GASTROINTESTINAL","Necrosis, GI","Stomach",3,"Inability to aliment adequately by GI tract (e.g., requiring enteral or parenteral nutrition); interventional radiology, endoscopic, or operative intervention indicated" "GASTROINTESTINAL","Necrosis, GI","Stomach",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Necrosis, GI","Stomach",5,"Death" "GASTROINTESTINAL","Obstruction, GI","Cecum",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Obstruction, GI","Cecum",2,"Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Obstruction, GI","Cecum",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Obstruction, GI","Cecum",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Obstruction, GI","Cecum",5,"Death" "GASTROINTESTINAL","Obstruction, GI","Colon",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Obstruction, GI","Colon",2,"Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Obstruction, GI","Colon",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Obstruction, GI","Colon",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Obstruction, GI","Colon",5,"Death" "GASTROINTESTINAL","Obstruction, GI","Duodenum",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Obstruction, GI","Duodenum",2,"Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Obstruction, GI","Duodenum",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Obstruction, GI","Duodenum",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Obstruction, GI","Duodenum",5,"Death" "GASTROINTESTINAL","Obstruction, GI","Esophagus",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Obstruction, GI","Esophagus",2,"Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Obstruction, GI","Esophagus",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Obstruction, GI","Esophagus",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Obstruction, GI","Esophagus",5,"Death" "GASTROINTESTINAL","Obstruction, GI","Gallbladder",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Obstruction, GI","Gallbladder",2,"Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Obstruction, GI","Gallbladder",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Obstruction, GI","Gallbladder",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Obstruction, GI","Gallbladder",5,"Death" "GASTROINTESTINAL","Obstruction, GI","Ileum",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Obstruction, GI","Ileum",2,"Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Obstruction, GI","Ileum",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Obstruction, GI","Ileum",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Obstruction, GI","Ileum",5,"Death" "GASTROINTESTINAL","Obstruction, GI","Jejunum",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Obstruction, GI","Jejunum",2,"Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Obstruction, GI","Jejunum",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Obstruction, GI","Jejunum",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Obstruction, GI","Jejunum",5,"Death" "GASTROINTESTINAL","Obstruction, GI","Rectum",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Obstruction, GI","Rectum",2,"Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Obstruction, GI","Rectum",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Obstruction, GI","Rectum",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Obstruction, GI","Rectum",5,"Death" "GASTROINTESTINAL","Obstruction, GI","Small bowel NOS",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Obstruction, GI","Small bowel NOS",2,"Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Obstruction, GI","Small bowel NOS",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Obstruction, GI","Small bowel NOS",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Obstruction, GI","Small bowel NOS",5,"Death" "GASTROINTESTINAL","Obstruction, GI","Stoma",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Obstruction, GI","Stoma",2,"Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Obstruction, GI","Stoma",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Obstruction, GI","Stoma",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Obstruction, GI","Stoma",5,"Death" "GASTROINTESTINAL","Obstruction, GI","Stomach",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Obstruction, GI","Stomach",2,"Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Obstruction, GI","Stomach",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, vomiting, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Obstruction, GI","Stomach",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Obstruction, GI","Stomach",5,"Death" "GASTROINTESTINAL","Perforation, GI","Appendix",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Perforation, GI","Appendix",2,"Medical intervention indicated; IV fluids indicated <24 hrs" "GASTROINTESTINAL","Perforation, GI","Appendix",3,"IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Perforation, GI","Appendix",4,"Life-threatening consequences" "GASTROINTESTINAL","Perforation, GI","Appendix",5,"Death" "GASTROINTESTINAL","Perforation, GI","Biliary tree",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Perforation, GI","Biliary tree",2,"Medical intervention indicated; IV fluids indicated <24 hrs" "GASTROINTESTINAL","Perforation, GI","Biliary tree",3,"IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Perforation, GI","Biliary tree",4,"Life-threatening consequences" "GASTROINTESTINAL","Perforation, GI","Biliary tree",5,"Death" "GASTROINTESTINAL","Perforation, GI","Cecum",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Perforation, GI","Cecum",2,"Medical intervention indicated; IV fluids indicated <24 hrs" "GASTROINTESTINAL","Perforation, GI","Cecum",3,"IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Perforation, GI","Cecum",4,"Life-threatening consequences" "GASTROINTESTINAL","Perforation, GI","Cecum",5,"Death" "GASTROINTESTINAL","Perforation, GI","Colon",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Perforation, GI","Colon",2,"Medical intervention indicated; IV fluids indicated <24 hrs" "GASTROINTESTINAL","Perforation, GI","Colon",3,"IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Perforation, GI","Colon",4,"Life-threatening consequences" "GASTROINTESTINAL","Perforation, GI","Colon",5,"Death" "GASTROINTESTINAL","Perforation, GI","Duodenum",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Perforation, GI","Duodenum",2,"Medical intervention indicated; IV fluids indicated <24 hrs" "GASTROINTESTINAL","Perforation, GI","Duodenum",3,"IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Perforation, GI","Duodenum",4,"Life-threatening consequences" "GASTROINTESTINAL","Perforation, GI","Duodenum",5,"Death" "GASTROINTESTINAL","Perforation, GI","Esophagus",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Perforation, GI","Esophagus",2,"Medical intervention indicated; IV fluids indicated <24 hrs" "GASTROINTESTINAL","Perforation, GI","Esophagus",3,"IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Perforation, GI","Esophagus",4,"Life-threatening consequences" "GASTROINTESTINAL","Perforation, GI","Esophagus",5,"Death" "GASTROINTESTINAL","Perforation, GI","Gallbladder",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Perforation, GI","Gallbladder",2,"Medical intervention indicated; IV fluids indicated <24 hrs" "GASTROINTESTINAL","Perforation, GI","Gallbladder",3,"IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Perforation, GI","Gallbladder",4,"Life-threatening consequences" "GASTROINTESTINAL","Perforation, GI","Gallbladder",5,"Death" "GASTROINTESTINAL","Perforation, GI","Ileum",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Perforation, GI","Ileum",2,"Medical intervention indicated; IV fluids indicated <24 hrs" "GASTROINTESTINAL","Perforation, GI","Ileum",3,"IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Perforation, GI","Ileum",4,"Life-threatening consequences" "GASTROINTESTINAL","Perforation, GI","Ileum",5,"Death" "GASTROINTESTINAL","Perforation, GI","Jejunum",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Perforation, GI","Jejunum",2,"Medical intervention indicated; IV fluids indicated <24 hrs" "GASTROINTESTINAL","Perforation, GI","Jejunum",3,"IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Perforation, GI","Jejunum",4,"Life-threatening consequences" "GASTROINTESTINAL","Perforation, GI","Jejunum",5,"Death" "GASTROINTESTINAL","Perforation, GI","Rectum",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Perforation, GI","Rectum",2,"Medical intervention indicated; IV fluids indicated <24 hrs" "GASTROINTESTINAL","Perforation, GI","Rectum",3,"IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Perforation, GI","Rectum",4,"Life-threatening consequences" "GASTROINTESTINAL","Perforation, GI","Rectum",5,"Death" "GASTROINTESTINAL","Perforation, GI","Small bowel NOS",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Perforation, GI","Small bowel NOS",2,"Medical intervention indicated; IV fluids indicated <24 hrs" "GASTROINTESTINAL","Perforation, GI","Small bowel NOS",3,"IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Perforation, GI","Small bowel NOS",4,"Life-threatening consequences" "GASTROINTESTINAL","Perforation, GI","Small bowel NOS",5,"Death" "GASTROINTESTINAL","Perforation, GI","Stomach",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Perforation, GI","Stomach",2,"Medical intervention indicated; IV fluids indicated <24 hrs" "GASTROINTESTINAL","Perforation, GI","Stomach",3,"IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Perforation, GI","Stomach",4,"Life-threatening consequences" "GASTROINTESTINAL","Perforation, GI","Stomach",5,"Death" "GASTROINTESTINAL","Proctitis",,1,"Rectal discomfort, intervention not indicated" "GASTROINTESTINAL","Proctitis",,2,"Symptoms not interfering with ADL; medical intervention indicated" "GASTROINTESTINAL","Proctitis",,3,"Stool incontinence or other symptoms interfering with ADL; operative intervention indicated" "GASTROINTESTINAL","Proctitis",,4,"Life-threatening consequences (e.g., perforation)" "GASTROINTESTINAL","Proctitis",,5,"Death" "GASTROINTESTINAL","Prolapse of stoma, GI",,1,"Asymptomatic" "GASTROINTESTINAL","Prolapse of stoma, GI",,2,"Extraordinary local care or maintenance; minor revision indicated" "GASTROINTESTINAL","Prolapse of stoma, GI",,3,"Dysfunctional stoma; major revision indicated" "GASTROINTESTINAL","Prolapse of stoma, GI",,4,"Life-threatening consequences" "GASTROINTESTINAL","Prolapse of stoma, GI",,5,"Death" "GASTROINTESTINAL","Salivary gland changes/saliva",,1,"Slightly thickened saliva; slightly altered taste (e.g., metallic)" "GASTROINTESTINAL","Salivary gland changes/saliva",,2,"Thick, ropy, sticky saliva; markedly altered taste; alteration in diet indicated; secretion-induced symptoms not interfering with ADL" "GASTROINTESTINAL","Salivary gland changes/saliva",,3,"Acute salivary gland necrosis; severe secretion-induced symptoms interfering with ADL" "GASTROINTESTINAL","Salivary gland changes/saliva",,4,"Disabling" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Anus",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Anus",2,"Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, bleeding, diarrhea); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Anus",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Anus",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Anus",5,"Death" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Biliary tree",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Biliary tree",2,"Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, bleeding, diarrhea); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Biliary tree",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Biliary tree",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Biliary tree",5,"Death" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Cecum",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Cecum",2,"Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, bleeding, diarrhea); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Cecum",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Cecum",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Cecum",5,"Death" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Colon",1,"Asymptomatic radiographic findings only" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Colon",2,"Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, bleeding, diarrhea); IV fluids indicated <24 hrs" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Colon",3,"Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated >=24 hrs; operative intervention indicated" "GASTROINTESTINAL","Stricture/stenosis (including anastomotic), GI","Colon",4,"Life-threatening consequences; operative intervention requiring complete organ resection (e.g., total colectomy)" "GASTROINTESTINAL","Stricture/stenosis (includin