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Last Updated: 08/18/23

NCI Experimental Therapeutics Clinical Trials Network (ETCTN)

2019 FOAs for the ETCTN and PK Resource Laboratories

Pre-application Webinar on Feb. 6, 2019, for ETCTN and PK Resources Laboratories

Overview/Objectives

The National Cancer Institute (NCI) has formed partnerships in the pharmaceutical industry, academic institutions, and individual investigators for the early clinical evaluation of innovative cancer therapies. The Experimental Therapeutics Clinical Trials Network (ETCTN) was created to evaluate these therapies using a coordinated, collaborative, and inclusive team-based approach to early phase experimental therapeutic clinical trials.

The objectives of the ETCTN are to:

  • Conduct early clinical trials of NCI-IND agents in high priority areas of unmet medical needs
  • Ensure efficient and timely activation and conduct of these clinical trials
  • Integrate preclinical findings using clinical samples for biomarker analysis
  • Promote collaboration among institutions and investigators
  • Integrate molecular characterization, pharmacology, cancer biology, and imaging into clinical trials

See the links in the sidebar for more information about the ETCTN.

ETCTN Participating Sites

ETCTN Phase 1 and Phase 2 Program Sites

ETCTN clinical sites (see map above) participate in a Phase 1 Program supported by UM1 grants, integrated with a Phase 2 Program supported by cooperative agreements as supplements to the existing phase 1 UM1 grant. By integrating Phase 1 and Phase 2 Program activities and administrative operations under the UM1 structure, ETCTN awardees will have the flexibility to expand phase 1 studies quickly upon detecting early activity signals.

LAO Organization
City of Hope Comprehensive Cancer Center LAO
USC / Norris Comprehensive Cancer Center
Children’s Hospital Los Angeles
Los Angeles County — USC Medical Center
Keck Medical Center of USC Pasadena
USC Norris Oncology/Hematology — Newport Beach
Keck Medicine of USC Buena Park
Keck Medicine of USC Koreatown
City of Hope Comprehensive Cancer Center
City of Hope South Pasadena
City of Hope Antelope Valley
City of Hope Corona
City of Hope Upland
City of Hope at Irvine Lennar
Stanford Cancer Institute Palo Alto
University of California Davis Comprehensive Cancer Center
Dana-Farber — Harvard Cancer Center LAO
Massachusetts General Hospital Cancer Center
Dana-Farber/Harvard Cancer Center
Brigham and Women’s Hospital
Beth Israel Deaconess Medical Center
Boston Medical Center
Mayo Clinic
Mayo Clinic in Arizona
Mayo Clinic Hospital in Arizona
Mayo Clinic in Florida
Laura and Isaac Perlmutter Cancer Center at NYU Langone
Bellevue Hospital Center
NYU Langone Hospital — Brooklyn
NYU Langone Hospital — Long Island
JHU Sidney Kimmel Comprehensive Cancer Center LAO
University of Colorado Hospital
MedStar Georgetown University Hospital
Hackensack University Medical Center
Emory University Hospital/Winship Cancer Institute
Emory Saint Joseph’s Hospital
Emory University Hospital Midtown
University of Maryland/Greenebaum Cancer Center
Johns Hopkins University/Sidney Kimmel Cancer Center
Sibley Memorial Hospital
Suburban Hospital
Johns Hopkins Bayview Medical Center
Wake Forest University Health Sciences
Hayworth Cancer Center
Wake Forest University at Clemmons
Wake Forest Baptist Health — Wilkes Medical Center
Wake Forest Baptist Health — Hematology Oncology — Statesville
Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Basking Ridge
Memorial Sloan Kettering Monmouth
Memorial Sloan Kettering Bergen
Memorial Sloan Kettering Commack
Memorial Sloan Kettering Nassau
Memorial Sloan Kettering Westchester
Thomas Jefferson University Hospital
University of Virginia Cancer Center
University of Wisconsin Carbone Cancer Center
National Cancer Institute LAO
NCI Center for Cancer Research
National Cancer Institute Developmental Therapeutics Clinic
National Institutes of Health Clinical Center
Ohio State University Comprehensive Cancer Center LAO
University of Kentucky/Markey Cancer Center
UNC Lineberger Comprehensive Cancer Center
NYP/Weill Cornell Medical Center
Ohio State University Comprehensive Cancer Center
JamesCare at Ohio State University Hospital East
Stefanie Spielman Comprehensive Breast Center
JamesCare Gynecologic Oncology at Mill Run
Huntsman Cancer Institute/University of Utah
South Jordan Health Center
Farmington Health Center
University of Utah Sugarhouse Health Center
UPMC Hillman Cancer Center LAO
UC Irvine Health/Chao Family Comprehensive Cancer Center
UC Irvine Health Cancer Center — Newport
Montefiore Medical Center — Einstein Campus
Montefiore Medical Center — Weiler Hospital
Montefiore Medical Center — Moses Campus
Children’s Hospital at Montefiore
UPMC Hillman Cancer Center
UPMC-Montefiore Hospital
UPMC Pinnacle Harrisburg
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
UPMC Susquehanna
University Health Network Princess Margaret Cancer Center LAO
University Health Network — Princess Margaret Hospital
University of Miami Miller School of Medicine — Sylvester Cancer Center
La Liga Contra el Cancer
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
UM Sylvester Comprehensive Cancer Center at Plantation
UM Sylvester Comprehensive Cancer Center at Hollywood
UM Sylvester Comprehensive Cancer Center at Kendall
UM Sylvester Comprehensive Cancer Center at Coral Springs
UM Sylvester Comprehensive Cancer Center at Coral Gables
UM Sylvester Comprehensive Cancer Center at Aventura
Moffitt Cancer Center
Moffitt Cancer Center — International Plaza
Moffitt Cancer Center — McKinley Campus
Northwestern University
Rutgers Cancer Institute of New Jersey
Rutgers Cancer Institute of New Jersey — Robert Wood Johnson University Hospital
Rhode Island Hospital
UT Southwestern/Simmons Cancer Center — Dallas
Parkland Memorial Hospital
UT Southwestern/Simmons Cancer Center — Fort Worth
UT Southwestern Clinical Center at Richardson/Plano
Virginia Commonwealth University/Massey Cancer Center
University of Texas MD Anderson Cancer Center LAO
M D Anderson Cancer Center
University of Texas Medical Branch
University of Texas Health Science Center at San Antonio
University of Texas at Austin
Yale University Cancer Center LAO
UC San Diego Moores Cancer Center
UC San Diego Medical Center — Hillcrest
UC San Diego Health System — Encinitas
Yale University
Smilow Cancer Hospital Care Center at Saint Francis
Smilow Cancer Center/Yale — New Haven Hospital
Smilow Cancer Hospital — Torrington Care Center
Smilow Cancer Hospital Care Center — Trumbull
Smilow Cancer Hospital Care Center — Guiford
Smilow Cancer Hospital — Waterbury Care Center
Smilow Cancer Hospital Care Center at Greenwich
Smilow Cancer Hospital — Orange Care Center
Smilow Cancer Hospital — Derby Care Center
Yale-New Haven Hospital North Haven Medical Center
Yale-New Haven Hospital North Haven Medical Center
Smilow Cancer Hospital Care Center — Waterford
Smilow Cancer Hospital Care Center — Fairfield
Smilow Cancer Hospital Care Center at Glastonbury
Smilow Cancer Hospital Care Center at Long Ridge
Smilow Cancer Hospital Care Center — Westerly
University of Florida Health Science Center — Gainesville
University of Kansas Cancer Center
Lawrence Memorial Hospital
Olathe Health Cancer Center
Ascension Via Christi — Pittsburg
Salina Regional Health Center
HaysMed
University of Kansas Health System Saint Francis Campus
University of Kansas Cancer Center — Overland Park
University of Kansas Hospital — Westwood Cancer Center
University of Kansas Hospital — Indian Creek Campus
University of Kansas Clinical Research Center
University Health Truman Medical Center
University of Kansas Cancer Center — Lee’s Summit
University of Kansas Cancer Center — North
University of Kansas Cancer Center at North Kansas City Hospital
Washington University School of Medicine
Barnes-Jewish Hospital
Siteman Cancer Center at Christian Hospital
Siteman Cancer Center at West County Hospital
Siteman Cancer Center at Saint Peters Hospital
Siteman Cancer Center-South County
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
University of Oklahoma Health Sciences Center
Vanderbilt University/Ingram Cancer Center
Vanderbilt Breast Center at One Hundred Oaks

*LAO = Lead Academic Organization

NCI Early Drug Development Opportunity Program (EDDOP)

Beginning in 2016, investigators from certain NCI-designated Cancer Centers not affiliated with the ETCTN may submit a Letter of Intent (LOI) and, if approved, receive full ETCTN support for the clinical trial. Non-ETCTN NCI Cancer Centers will also be able to compete for administrative supplements to enroll patients on select ETCTN phase 2 trials. Click here for more information about the EDDOP.

NCI-sponsored Infrastructure for ETCTN Trials

ETCTN trials are supported by integrated centralized clinical and administrative services sponsored by NCI. More details, and links to each service, may be found here.