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U.S. National Institutes of Health
Last Updated: 03/20/13

CTCAE v4.0 Open Comment Period

CTEP is currently accepting and encouraging open comment on CTCAE v4.0.

The comment period will close April 15, 2013. Suggested improvements will be considered for integration into CTCAE v5.0.

Send all comments to ncictcaehelp@mail.nih.gov. Examples of comments include requests for additional terms, changes to the grading for current terms, and requests for clarification or examples of confusing language. Please be as specific as possible.

CTCAE is widely accepted throughout the oncology research community as the standard grading scale for adverse events. Your feedback helps improve the user experience, accuracy of reporting and classification of side effects used in assessing drugs for cancer therapy.

Common Terminology Criteria for Adverse Events (CTCAE)

Common Terminology Criteria for Adverse Events (CTCAE) v4.0

CTCAE v4.0
This link takes you to the NCI repository for all CTCAE v4.0 related documents including PDF, Microsoft Excel and OWL formats.

SOP for Resolving CDUS Merges
CTEP has developed an SOP for resolving merging issues associated with converting CTC v2.0 or CTCAE v3.0 protocols to CTCAE v4.0.

CTEP Guidance: CTCAE v4.0 Grading Scales with Numeric Component
In response to increasing use of lab interfaces for assistance with grading lab values, CTEP has published a CTEP Guidance: CTCAE v4.0 Grading Scales with Numeric Component.

CTC/CTCAE Mapping Documents

Retired CTC and CTCAE Versions Archive