Childhood Cancer Resources
- Patient/Caregiver Ad Hoc Education Template
- Pediatric Clinical Trials Cooperative Groups and Consortia
- Pediatric Preclinical Testing Consortium (PPTC)
- Information regarding the inclusion and protection of children enrolled on
Federally supported clinical trials
- FDA Pediatric Resources
- Reports from CTEP-Sponsored Childhood Cancer Meetings
Pediatric Clinical Trials Cooperative Groups and Consortia
The Children’s Oncology Group (C.O.G.) is supported by the National Cancer Institute to conduct clinical trials devoted exclusively to children and adolescents with cancer. C.O.G. develops and coordinates cancer clinical trials conducted at its more than 200 member institutions, which include cancer centers of all major universities and teaching hospitals throughout the U.S. and Canada, as well as sites in Europe and Australia. C.O.G. members include over 5000 cancer researchers dedicated to saving the lives of children with cancer. C.O.G. was formed by the merger of the four previous children’s cancer cooperative groups (CCG, POG, IRSG, NWTSG) in order to accelerate the search for a cure for the cancers of children. Through the C.O.G. network of member institutions, children with cancer, regardless of where they live, can access state-of-the art therapies and the collective expertise of world-renowned pediatric specialists.
Children’s Oncology Group (C.O.G.) Phase 1/Pilot Consortium
The primary objective of the C.O.G. Phase 1/Pilot Consortium is to expeditiously develop and implement pediatric phase 1 and pilot studies, thus facilitating the integration of advances in cancer biology and therapy in the treatment of childhood cancer. The Consortium includes approximately 20 institutions. Pharmacokinetic and biological correlative studies are key components of the consortium’s phase 1 trials and are increasingly important for new agents with specific molecular targets. The Consortium is funded to conduct pilot studies of promising multi-agent regimens (which may or may not involve a dose escalation). These studies are an important step in the integration of new agents into the therapy of specific childhood cancers and require careful monitoring for toxicity and safety such as can be provided by the Consortium’s member institutions. After their initial evaluation for safety in children by the Consortium, the agents and regimens can then be studied within the larger group of C.O.G. institutions to determine their role for in the treatment of specific childhood cancers.
The primary objective of the PBTC is to rapidly conduct phase 1 and 2 clinical evaluations of new therapeutic drugs, intrathecal agents, delivery technologies, biological therapies, and radiation treatment strategies in children age 0 – 21 years of age with primary CNS tumors. The PBTC includes nine leading academic institutions with extensive experience in the design and conduct of childhood cancer clinical trials for children with brain tumors. Another objective of the PBTC is to develop and coordinate innovative neuroimaging techniques on a consortium-wide basis. Results from PBTC studies will be available to large international collaborative groups for confirmatory phase 2 and multiagent phase 3 clinical trials. Specifically, direct interactions have been established with the Children's Oncology Group. This collaborative interaction assures a rapid transition from phase 1 and 2 trials conducted by the PBTC.
NANT is a consortium of University and Children’s Hospitals funded by the NCI to test promising new therapies for neuroblastoma. NANT members constitute a group of closely collaborating investigators who are linked with laboratory programs developing novel therapies for high-risk neuroblastoma. The group conducts limited-institution clinical trials to test new drugs and new combinations of drugs against high-risk neuroblastoma with the goal that promising therapies can be tested nationally.
The Childhood Cancer Survivor Study (CCSS) was created to gain new knowledge about the long-term effects of cancer and its therapy. This knowledge can help design treatment protocols and intervention strategies that will increase survival and minimize harmful health effects. The CCSS also serves to educate survivors about the potential impacts of cancer diagnosis and treatment on their health, and to provide follow-up care, for example, by creating and implementing programs for the prevention and early detection of late effects. The CCSS is a component of the Long-Term Follow-Up Study, a collaborative, multi-institutional study, funded by the National Cancer Institute, of individuals who survived five or more years after treatment for cancer, leukemia, tumor, or similar illness diagnosed during childhood or adolescence. The CCSS is a retrospectively ascertained cohort of 20,346 childhood cancer survivors diagnosed between 1970 and 1986; it also includes approximately 3,500 siblings of survivors, who serve as control subjects for the study. The CCSS cohort has been assembled through the efforts of 27 participating centers in the United States and Canada and is coordinated by investigators at the University of Minnesota. Initiated in 1993, the study was recently funded by the National Cancer Institute for continuation through 2004.
Information regarding the inclusion and protection of children enrolled on Federally supported clinical trials
- Federal Policy for the Protection of Human Subjects
45 Code of Federal Regulations 46
Complete document regarding human subjects protection
- Subpart D-Additional DHHS Protections for Children Involved as Subjects in Research
45 Code of Federal Regulations 46, Subpart D
- IRB Guidebook
Guidance for Institutional Review Boards when reviewing clinical protocols
- IRB Guidebook,
CHAPTER VI: SPECIAL CLASSES OF SUBJECTS
C. CHILDREN AND MINORS
Guidance for Institutional Review Boards when considering clinical protocols that will include children
- NIH policy and guidelines on the inclusion of children as participants in research involving human subjects
- Interim Rule (FDA): Additional Safeguards for Children in Clinical Investigations of FDA-Regulated Products. (April 26, 2001)
- Report from the National Human Research Protections Advisory Committee on Clarifying Specific Portion of 45 CFR 46 Subpart D that Governs Children’s Research.
FDA Pediatric Resources
The FDA Office of Pediatric Therapeutics web site has a wide range of information relevant to clinical research involving children, including information on guidance documents and regulations related to pediatric drug development.
Reports from CTEP-Sponsored
Childhood Cancer Meetings
- Summary of Childhood Cancer Targeted Therapeutics Workshop Sponsored by the American Cancer Society and the National Cancer Institute (May 5-6, 2005)
- Cancer Pharmacology in Infants and Young Children (December 23, 2003) (Word)
- Epidemiological Approaches to Testing the Population Mixing Hypothesis (March 27, 2002) (PDF)
- Report of the Phase 2 Window Meeting (July 22, 1997)