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Last Updated: 09/08/17

NCI Registration and Credential Repository (RCR)

Food and Drug Administration (FDA) regulations require IND sponsors to select qualified investigators. NCI policy requires all persons participating in any NCI-sponsored clinical trial to register and renew their registration annually.

Registration is accomplished via the NCI Registration and Credential Repository (RCR).

RCR utilizes FIVE person registration types.

  • Investigator (IVR) — MD, DO, or international equivalent
  • Non-Physician Investigator (NPIVR) — advanced practice providers (e.g., NP or PA) or graduate level researchers (e.g., PhD)
  • Associate Plus (AP) — clinical site staff (e.g., RN or CRA) with data entry access to CTSU applications (e.g., RUMS, OPEN, RAVE, TRIAD)
  • Associate (A) — other clinical site staff involved in the conduct of NCI-sponsored trials
  • Associate Basic (AB) — individuals (e.g., pharmaceutical company employees) with limited access to NCI-supported systems

RCR requires the following registration documents:

Documentation Required IVR NPIVR AP A AB
FDA Form 1572
Financial Disclosure Form
NCI Biosketch (education, training, employment, license, and certification)
HSP/GCP training
Agent Shipment Form (if applicable)
CV (optional)

RCR Related Links

RCR Presentations and Checklists

RCR WebEx presentation

Introduction to CTEP’s Registration and Credential Repository (RCR)

RCR Quick Reference Guide

RCR Registration Type Checklists:


How do I prepare for creating a Registration and Credential Repository (RCR) profile?

When do I have to re-register in RCR?

I have a new clinical site staff person (IVR, NPIVR, AP, or A). Where do I start?

I have my CTEP Person ID; but, I need to register as an IVR, NPIVR, or AP. What next?

I’m unable to add my Investigator to one of our clinical sites. What do I do?

I’m trying to enroll a patient in OPEN and the investigator I need to select as the credit, treating, or drug shipment investigator does not have the IRB of record on their FDA Form 1572. What do I do?