Common Terminology Criteria for Adverse Events (CTCAE)

• CTEP/NCORP Guidance for Collection of Adverse Events Related to COVID-19 Infection (3/25/2020)
• Common Terminology Criteria for Adverse Events (CTCAE) v6.0
• Common Terminology Criteria for Adverse Events (CTCAE) v5.0
• Common Terminology Criteria for Adverse Events (CTCAE) v4.0
• CTEP Guidance: CTCAE v4.0 Grading Scales with Numeric Component
• Responsible Adverse Event (AE) Reporting: Finding Appropriate AE Terms
• CTC and CTCAE Versions Archive
• CTC/CTCAE Dictionary and Index
  The CTCAE Dictionary is a web-based application to assist in locating appropriate adverse event terms from CTCAE v4.0.

Common Terminology Criteria for Adverse Events (CTCAE) v6.0

NCI has set Fall 2022 as the anticipated publication date for the next version of CTCAE (version 6.0). These next two years will be utilized to analyze change requests and create revisions. Your input is valuable and will help make CTCAE a better tool. The current version (v5.0) of CTCAE is available for review here: https://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm#ctc_50

Please forward any additions, deletions, or change requests to ncictcaecomments@mail.nih.gov by October 30, 2020.

• CTCAE v6.0 Solicitation of Changes Brief Overview

Common Terminology Criteria for Adverse Events (CTCAE) v5.0

• CTCAE v5.0 Clean, Tracked, and Mapping Document (Excel) (November 27, 2017)
• CTCAE v5.0 Quick Reference 5x7 (PDF) (November 27, 2017)
• CTCAE v5.0 Quick Reference 8.5x11 (PDF) (November 27, 2017)
• Conversion of CDUS Data from CTC v4.0 to CTCAE v5.0 (PDF) (January 5, 2018)
• CTCAE v5.0 Conversion Amendment Request (PDF) (January 25, 2018)

Common Terminology Criteria for Adverse Events (CTCAE) v4.0

• CTCAE v4.03 (Excel) (June 14, 2010)

CTC and CTCAE Versions Archive

• Common Terminology Criteria for Adverse Events (CTCAE) v4.0
  • CTCAE v4.0 Archive
  • CTCAE v3.0 (MedDRA 10.0) to CTCAE v4.0 (MedDRA 12.1) (Excel) (June 14, 2010)
  • CTCAE v4.0 (MedDRA 12.1) to CTCAE v3.0 (MedDRA 10.0) (Excel) (December 23, 2009)
  • CTCAE v4.0 and Lay Term Mapping Document (PDF)
  • SOP for Resolving CDUS Merges
• Common Terminology Criteria for Adverse Events (CTCAE) v3.0
  • CTCAE v3.0 (PDF) (Publish Date August 9, 2006)
  • CTCAE v3.0 Notice of Modifications (PDF) (Publish Date August 9, 2006)
  • CTCAE v3.0 and Lay Term Mapping Document - Cover Memo (MS Word)
  • CTCAE v3.0 and Lay Term Mapping Document (Excel)
• Common Toxicity Criteria (CTC) v2.0
  • CTC v2.0 (PDF) (Publish Date April 30,1999)
  • Common Toxicity Criteria Manual (PDF) (Updated August 18,1999)
  • Common Toxicity Criteria Index Terms (PDF) (Updated July 21, 1999)
  • Common Toxicity Criteria (PDF) - Notice of Modifications (Publish Date April 30,1999)
  • CTC — Version 2.0 (Microsoft Access 97 Database)
  • CTC v2.0 (MedDRA 10.0) to CTCAE v3.0 (MedDRA 10.0) (Excel) (February 25, 2010)
  • CTC v2.0 to CTCAE v3.0 with Short Names (Excel) (October 7, 2003)